Unveiling the therapeutic potential of squalene synthase: Deciphering its biochemical mechanism, disease implications, and intriguing ties to ferroptosis
DF Picón, R Skouta - Cancers, 2023 - mdpi.com
Simple Summary Squalene synthase is a key enzyme that not only participates in the
mevalonate pathway, resulting in cholesterol, but also acts as a potential ferroptosis …
mevalonate pathway, resulting in cholesterol, but also acts as a potential ferroptosis …
Lipid-Centric Approaches in Combating Infectious Diseases: Antibacterials, Antifungals and Antivirals with Lipid-Associated Mechanisms of Action
OS Ostroumova, SS Efimova - Antibiotics, 2023 - mdpi.com
One of the global challenges of the 21st century is the increase in mortality from infectious
diseases against the backdrop of the spread of antibiotic-resistant pathogenic …
diseases against the backdrop of the spread of antibiotic-resistant pathogenic …
Oxysterols protect epithelial cells against pore-forming toxins
TJR Ormsby, SE Owens, L Clement, TJ Mills… - Frontiers in …, 2022 - frontiersin.org
Many species of bacteria produce toxins such as cholesterol-dependent cytolysins that form
pores in cell membranes. Membrane pores facilitate infection by releasing nutrients …
pores in cell membranes. Membrane pores facilitate infection by releasing nutrients …
[HTML][HTML] Oxysterols protect bovine endometrial cells against pore-forming toxins from pathogenic bacteria
TJR Ormsby, SE Owens, AD Horlock… - … : official publication of …, 2021 - ncbi.nlm.nih.gov
Many species of pathogenic bacteria secrete toxins that form pores in mammalian cell
membranes. These membrane pores enable the delivery of virulence factors into cells, result …
membranes. These membrane pores enable the delivery of virulence factors into cells, result …
Glucocorticoids increase tissue cell protection against pore-forming toxins from pathogenic bacteria
Many species of pathogenic bacteria damage tissue cells by secreting toxins that form pores
in plasma membranes. Here we show that glucocorticoids increase the intrinsic protection of …
in plasma membranes. Here we show that glucocorticoids increase the intrinsic protection of …
Statins as Potential Preventative Treatment of ETX and Multiple Pore-Forming Toxin-Induced Diseases
J Huang, B Zhao, T Liu, L Kang, J Li, Z Guo… - International Journal of …, 2023 - mdpi.com
Epsilon toxin (ETX), produced by type B and D strains of Clostridium perfringens, can cause
fatal enterotoxaemia in ruminant animals, particularly sheep, cattle, and goats. Previous …
fatal enterotoxaemia in ruminant animals, particularly sheep, cattle, and goats. Previous …
Inhibitors of Farnesyl Diphosphate Synthase and Squalene Synthase: Potential Source for Anti-Trypanosomatidae Drug Discovery
BP Kamdem, FF Boyom - Drugs and Drug Candidates, 2023 - mdpi.com
Trypanosomatids are mainly responsible for leishmaniasis, sleeping sickness, and Chagas
disease, which are the most challenging among the neglected tropical diseases due to the …
disease, which are the most challenging among the neglected tropical diseases due to the …