CD38 is a molecule that can act as an enzyme, with NAD-depleting and intracellular
signaling activity, or as a receptor with adhesive functions. CD38 can be found expressed …

In ischemic stroke, the primary neuronal injury caused by the disruption of energy supply is
further exacerbated by secondary sterile inflammation. The inflammatory cascade is largely …

Neurons can release damaged mitochondria and transfer them to astrocytes for disposal
and recycling. This ability to exchange mitochondria may represent a potential mode of cell …

Macrophages and their monocyte precursors mediate innate immune responses and can
promote a spectrum of phenotypes from pro-inflammatory to pro-resolving. Currently, there …

Neurodegenerative diseases are characterized by neuronal degeneration as well as
neuroinflammation. While CD38 is strongly expressed in brain cells including neurons …

Background: Preclinical studies, clinical trials, and reviews suggest increasing 3', 5'-cyclic
adenosine monophosphate (cAMP) and 3', 5'-cyclic guanosine monophosphate (cGMP) with …

Stroke is one of the leading causes of death worldwide. At present, the only available
treatment is thrombolysis, which should be initiated no later than 4.5 hours after onset of …

Nicotinamide adenine dinucleotide (NAD+) is an essential cofactor for multiple cellular
metabolic reactions and has a central role in energy production. Brain ischemia depletes …

Background—Endogenous arginine homologues, including homoarginine, have been
identified as novel biomarkers for cardiovascular disease and outcomes. Our studies of …

Cluster of differentiation 38 (CD38) is a cell surface glycoprotein and multifunctional
extracellular enzyme. As a NADase, CD38 produces adenosine through the adenosine …