Even though enzymes are the cornerstones of living systems, it has so far proven difficult to
deploy artificial catalysts in a biological setting. Organocatalysts are arguably well-suited …

Proteins are multifunctional large organic compounds that constitute an essential
component of a living system. Hence, control over their bioconjugation impacts science at …

Chemical modification of proteins provides powerful tools to realize a broad range of
exciting biological applications, including the development of new classes of …

Histidine (His) carries a unique heteroaromatic imidazole side chain and plays irreplaceable
functional roles in peptides and proteins. Existing strategies for site-selective histidine …

Protein acetylation is a central event in orchestrating diverse cellular processes. However,
current strategies to investigate protein acetylation in cells are often nonspecific or lack …

Protein analysis under biological conditions is now regarded as indispensable for
understanding the structure and function of proteins, in addition to in vitro studies using …

The Click reaction that involves Cu (I)-catalyzed azide–alkyne cycloaddition (CuAAC) serves
as the most potent and highly dependable tool for the development of many complex …

Chemical modification of proteins is important for creating a myriad of engineered proteins
and for elucidating the function and dynamics of proteins in live cells. A wide variety of …

The necessity for precision labeling of proteins emerged during the efforts to understand and
regulate their structure and function. It demands selective attachment of tags such as affinity …

Peptides are privileged ligands for diverse biomacromolecules, including proteins; however,
their utility is often limited due to low membrane permeability and in-cell instability. Here, we …