Nuclear factor κB (NF-κB) is a dimeric transcription factor constituted by two of five protein
family members. It plays an essential role in inflammation and immunity by regulating the …

The transcription factor NF-κB is a central mediator of inflammation with multiple links to
thrombotic processes. In this review, we focus on the role of NF-κB signaling in cell types …

Dysregulated inflammation is a central pathological process in diverse disease states.
Traditionally, therapeutic approaches have sought to modulate the pro-or anti-inflammatory …

An effective resolution program may be able to prevent the progression from non-resolving
acute inflammation to persistent chronic inflammation. It has now become evident that …

Macrophages are strategically located throughout the body tissues, where they ingest and
process foreign materials, dead cells and debris and recruit additional macrophages in …

With the development of nanotechnology, significant progress has been made in the design,
and manufacture of nanoparticles (NPs) for use in clinical treatments. Recent increases in …

Macrophages can be polarized into classically activated macrophages (M1) and
alternatively activated macrophages (M2) in the immune system, performing pro …

The nuclear factor NF-κB pathway has long been considered a prototypical proinflammatory
signaling pathway, largely based on the role of NF-κB in the expression of proinflammatory …

NF-κB was first discovered and characterized 25 years ago as a key regulator of inducible
gene expression in the immune system. Thus, it is not surprising that the clearest biological …

Tumor-associated macrophages (TAM) form a major component of the tumor stroma.
However, important concepts such as TAM heterogeneity and the nature of the monocytic …