In the last decade, the sequence-specific transcription factor double homeobox 4 (DUX4)
has gone from being an obscure entity to being a key factor in important physiological and …

Although the pathophysiology of facioscapulohumeral dystrophy (FSHD) has been
controversial over the last decades, progress in recent years has led to a model that …

Facioscapulohumeral muscular dystrophy (FSHD) is a common form of muscular dystrophy
in adults that is foremost characterized by progressive wasting of muscles in the upper body …

Objective: Facioscapulohumeral muscular dystrophy (FSHD) is associated with D4Z4 repeat
contraction on human chromosome 4q35. This genetic lesion does not result in complete …

Background Facioscapulohumeral muscular dystrophy (FSHD) is linked to deletions in 4q35
within the D4Z4 repeat array in which we identified the dou ble homeobo x 4 (DUX4) gene …

The genome is the most functional part of a cell, and genomic contents are organized in a
compact three-dimensional (3D) structure. The genome contains millions of nucleotide …

Facioscapulohumeral muscular dystrophy (FSHD) is the third most common muscular
dystrophy after the dystrophinopathies and myotonic dystrophy and is associated with a …

In recent years, growing evidence has suggested a prominent role of oxidative stress in the
pathophysiology of several early-and adult-onset muscle disorders, although effective …

Generation of skeletal muscles with forms adapted to their function is essential for normal
movement. Muscle shape is patterned by the coordinated polarity of collectively migrating …

DNA is organized into complex three-dimensional chromatin structures, but how this spatial
organization regulates gene expression remains a central question. These DNA/chromatin …