Peroxynitrite is a short-lived and reactive biological oxidant formed from the diffusion-
controlled reaction of the free radicals superoxide (O2•–) and nitric oxide (• NO). In this …

Endoplasmic reticulum (ER) is a dynamic organelle orchestrating the folding and post-
translational maturation of almost all membrane proteins and most secreted proteins. These …

Peroxiredoxins (Prxs) are a ubiquitous family of cysteine-dependent peroxidase enzymes
that play dominant roles in regulating peroxide levels within cells. These enzymes, often …

Over the last decade, a dual character of cell response to oxidative stress, eustress versus
distress, has become increasingly recognized. A growing body of evidence indicates that …

Peroxiredoxins (Prxs) are a very large and highly conserved family of peroxidases that
reduce peroxides, with a conserved cysteine residue, designated the “peroxidatic” Cys (CP) …

Reactive oxygen species (ROS) have been shown to be toxic but also function as signalling
molecules. This biological paradox underlies mechanisms that are important for the integrity …

Redox-dependent processes influence most cellular functions, such as differentiation,
proliferation, and apoptosis. Mitochondria are at the center of these processes, as …

Significance: Disulfides are important building blocks in the secondary and tertiary structures
of proteins, serving as inter-and intra-subunit cross links. Disulfides are also the major …

Peroxiredoxins (Prxs) contain an active site cysteine that is sensitive to oxidation by H 2 O 2.
Mammalian cells express six Prx isoforms that are localized to various cellular …

This review focuses on the role of oxidative processes in atherosclerosis and its resultant
cardiovascular events. There is now a consensus that atherosclerosis represents a state of …