Epigenetic modifications established during gametogenesis regulate transcription and other
nuclear processes in gametes, but also have influences in the zygote, embryo and postnatal …

Epigenetic information in the mammalian oocyte has the potential to be transmitted to the
next generation and influence gene expression; this occurs naturally in the case of imprinted …

Background In the mouse, the patterns of DNA methylation are established during early
embryonic development in the epiblast. We quantified the targets and kinetics of DNA …

Background Emerging evidence suggests that maternal folate status can impact cognitive
development in childhood. Folate-dependent DNA methylation may provide a biological …

Critical roles for DNA methylation in embryonic development are well established, but less is
known about its roles during trophoblast development, the extraembryonic lineage that gives …

Background Metabolic stress associated with negative energy balance in high producing
dairy cattle and obesity in women is a risk factor for decreased fertility. Non-esterified fatty …

Children conceived by assisted reproductive technologies (ART) have a moderate risk for a
number of adverse events and conditions. The question whether this additional risk is …

Understanding the molecular level changes of oocyte cryopreservation and the subsequent
warming process is essential for improving the oocyte cryopreservation technologies. Here …

Background Maternal blood folate concentrations during pregnancy have been previously
linked with DNA methylation patterns, but this has been done predominantly through …

MicroRNAs (miRNAs) play vital roles in the development of oocytes and ovarian follicles. We
have previously shown differential expression of miR‐342‐3p during yak oocyte maturation …