Eye development has been a paradigm for the study of organogenesis, from the
demonstration of lens induction through epithelial tissue morphogenesis, to neuronal …

Two fundamental principles can account for how regulated networks of interacting proteins
originated in cells. These are the law of mass action, which holds that the binding of one …

The eukaryotic replisome, organized around the Cdc45-MCM-GINS (CMG) helicase,
orchestrates chromosome replication. Multiple factors associate directly with CMG, including …

The gene apparently responsible for a heritable form of murine pituitary-dependent dwarfism
(Ames dwarf, df) has been positionally cloned, identifying a novel, tissue-specific, paired-like …

During early mouse development the homeobox gene Hesx1 is expressed in prospective
forebrain tissue, but later becomes restricted to Rathke's pouch, the primordium of the …

Genes associated with inherited retinal degeneration have been found to encode proteins
required for phototransduction, metabolism, or structural support of photoreceptors. Here we …

Genomic rearrangement of the antigen receptor loci is initiated by the two lymphoid-specific
proteins Rag-1 and Rag-2. Null mutations in either of the two proteins abrogate initiation of V …

▪ Abstract Pax-6 is a member of the Pax gene class and encodes a protein containing a
paired domain and a homeodomain. The molecular characterization of Pax-6 genes from …

Polyamide dimers containing three types of aromatic rings—pyrrole, imidazole, and
hydroxypyrrole—afford a small-molecule recognition code that discriminates among all four …

We identified mutations in the VSX1 homeobox gene for two distinct inherited corneal
dystrophies; posterior polymorphous dystrophy (PPD) and keratoconus. One of the mutation …