The SLC4 family of bicarbonate (HCO3-) transporters
The SLC4 family consists of 10 genes (SLC4A1–5; SLC4A7–11). All encode integral
membrane proteins with very similar hydropathy plots—consistent with 10–14 …
membrane proteins with very similar hydropathy plots—consistent with 10–14 …
The divergence, actions, roles, and relatives of sodium-coupled bicarbonate transporters
MD Parker, WF Boron - Physiological reviews, 2013 - journals.physiology.org
The mammalian Slc4 (Solute carrier 4) family of transporters is a functionally diverse group
of 10 multi-spanning membrane proteins that includes three Cl-HCO3 exchangers (AE1–3) …
of 10 multi-spanning membrane proteins that includes three Cl-HCO3 exchangers (AE1–3) …
Physiology, pharmacology and pathophysiology of the pH regulatory transport proteins NHE1 and NBCn1: similarities, differences, and implications for cancer therapy
E Boedtkjer, L Bunch… - Current pharmaceutical …, 2012 - ingentaconnect.com
The Na+/H+-exchanger 1, NHE1 (SLC9A1) and the electroneutral Na+, HCO3--
cotransporter NBCn1 (SLC4A7) are coexpressed in a wide range of tissues. Under normal …
cotransporter NBCn1 (SLC4A7) are coexpressed in a wide range of tissues. Under normal …
SLC4 base (HCO3−, CO32−) transporters: classification, function, structure, genetic diseases, and knockout models
A Pushkin, I Kurtz - American Journal of Physiology-Renal …, 2006 - journals.physiology.org
In prokaryotic and eukaryotic organisms, biochemical and physiological processes are
sensitive to changes in H+ activity. For these processes to function optimally, a variety of …
sensitive to changes in H+ activity. For these processes to function optimally, a variety of …
Bicarbonate transport in health and disease
K Alka, JR Casey - IUBMB life, 2014 - Wiley Online Library
Abstract Bicarbonate (HCO3−) has a central place in human physiology as the waste
product of mitochondrial energy production and for its role in pH buffering throughout the …
product of mitochondrial energy production and for its role in pH buffering throughout the …
Structure and Function of SLC4 Family Transporters
Y Liu, J Yang, LM Chen - Frontiers in physiology, 2015 - frontiersin.org
The solute carrier SLC4 family consists of 10 members, nine of which are HCO 3-
transporters, including three Na+-independent Cl−/HCO 3-exchangers AE1, AE2, and AE3 …
transporters, including three Na+-independent Cl−/HCO 3-exchangers AE1, AE2, and AE3 …
Human FK506 Binding Protein 65 Is Associated with Colorectal Cancer* S
SH Olesen, LL Christensen, FB Sørensen… - Molecular & Cellular …, 2005 - ASBMB
We initiated the present study to identify new genes associated with colorectal cancer. In a
previously published microarray study an EST (W80763), later identified as the gene …
previously published microarray study an EST (W80763), later identified as the gene …
Antibody-independent localization of the electroneutral Na+-HCO3− cotransporter NBCn1 (slc4a7) in mice
E Boedtkjer, J Praetorius… - American Journal of …, 2008 - journals.physiology.org
The expression pattern of the electroneutral Na+-HCO3− cotransporter NBCn1 (slc4a7) was
investigated by β-galactosidase staining of mice with a LacZ insertion into the NBCn1 gene …
investigated by β-galactosidase staining of mice with a LacZ insertion into the NBCn1 gene …
Na+-dependent HCO3− uptake into the rat choroid plexus epithelium is partially DIDS sensitive
EV Bouzinova, J Praetorius, LV Virkki… - … of Physiology-Cell …, 2005 - journals.physiology.org
Several studies suggest the involvement of Na+ and HCO3− transport in the formation of
cerebrospinal fluid. Two Na+-dependent HCO3− transporters were recently localized to the …
cerebrospinal fluid. Two Na+-dependent HCO3− transporters were recently localized to the …
[HTML][HTML] Cation-coupled bicarbonate transporters
Cation-coupled HCO 3− transport was initially identified in the mid-1970s when pioneering
studies showed that acid extrusion from cells is stimulated by CO 2/HCO 3− and associated …
studies showed that acid extrusion from cells is stimulated by CO 2/HCO 3− and associated …