Glucose metabolism is normally regulated by a feedback loop including islet β cells and
insulin-sensitive tissues, in which tissue sensitivity to insulin affects magnitude of β-cell …

Diabetes mellitus is a medical condition characterized by the body's loss of control over
blood sugar. The frequency of diagnosed cases and consequential increases in medical …

Ganoderma lucidum comprises probably 400 different biologically active constituents
principally polysaccharides, triterpenoids, proteins, enzymes, steroids, sterols, nucleotides …

Type 2 diabetes mellitus is characterized by the dysregulation of glucose homeostasis,
resulting in hyperglycaemia. Although current diabetes treatments have exhibited some …

The increasing prevalence, variable pathogenesis, progressive natural history, and
complications of type 2 diabetes emphasise the urgent need for new treatment strategies …

Metabolic reprogramming is a hallmark of cancer cells and contributes to their adaption
within the tumour microenvironment and resistance to anticancer therapies. Recently …

Type 2 diabetes mellitus, a common metabolic and endocrine disorder worldwide, causes
severe health and economic problems. At present, pharmacotherapy involving synthetic …

Ganoderma lucidum is a white rot fungus widely used as a tonic for the promotion of
longevity and health. Extracts of G. lucidum have been recognized as an alternative …

Islet dysfunction—characterized by a combination of defective insulin secretion,
inappropriately high glucagon secretion and reduced β-cell mass—has a central role in the …

Conversion of glucose into glycogen is a major pathway that contributes to the removal of
glucose from the portal vein by the liver in the postprandial state. It is regulated in part by the …