Quinoline as a privileged scaffold in cancer drug discovery
V R. Solomon, H Lee - Current medicinal chemistry, 2011 - benthamdirect.com
Quinoline (1-azanaphthalene) is a heterocyclic aromatic nitrogen compound characterized
by a double-ring structure that contains a benzene ring fused to pyridine at two adjacent …
by a double-ring structure that contains a benzene ring fused to pyridine at two adjacent …
Quinoline: a promising antitubercular target
Tuberculosis (TB) remains a global public health problem in recent years. TB originated
mainly from various strains of Mycobacterium tuberculosis, is a highly infectious and chronic …
mainly from various strains of Mycobacterium tuberculosis, is a highly infectious and chronic …
Contemporary challenges in the design of topoisomerase II inhibitors for cancer chemotherapy
C Bailly - Chemical reviews, 2012 - ACS Publications
1. INTRODUCTION The length of straightened-out DNA in a single cell is nearly 2 m. In
mammalian cells, the nucleus has a diameter of approximately 6 μm and occupies about …
mammalian cells, the nucleus has a diameter of approximately 6 μm and occupies about …
Coumarin hybrid derivatives as promising leads to treat tuberculosis: Recent developments and critical aspects of structural design to exhibit anti-tubercular activity
Tuberculosis (TB) is a highly contagious airborne disease with nearly 25% of the world's
population infected with it. Challenges such as multi drug resistant TB (MDR-TB), extensive …
population infected with it. Challenges such as multi drug resistant TB (MDR-TB), extensive …
[HTML][HTML] A review on quinoline hydrazone derivatives as a new class of potent antitubercular and anticancer agents
MC Mandewale, UC Patil, SV Shedge… - Beni-Suef University …, 2017 - Elsevier
Tuberculosis (TB) and Cancer remains a global public health problem in recent years. There
is an urgent need for the screening of new bioactive molecules with new targets and with a …
is an urgent need for the screening of new bioactive molecules with new targets and with a …
[HTML][HTML] Secondary metabolites as DNA topoisomerase inhibitors: a new era towards designing of anticancer drugs
S Baikar, N Malpathak - Pharmacognosy reviews, 2010 - ncbi.nlm.nih.gov
A large number of secondary metabolites like alkaloids, terpenoids, polyphenols and
quinones are produced by the plants. These metabolites can be utilized as natural …
quinones are produced by the plants. These metabolites can be utilized as natural …
Quinoline-based anti-oncogenic molecules: synthesis and biological evaluation
Quinoline and its analogues are found in various natural products, many of which are active
pharmacophores with significant bioactivities. This article discussed the plethora of …
pharmacophores with significant bioactivities. This article discussed the plethora of …
Advances in the chemistry of natural and semisynthetic topoisomerase I/II inhibitors
VA D'yakonov, LU Dzhemileva… - Studies in natural products …, 2017 - Elsevier
The search for new, effective, and low-toxic anticancer agents is one of the most important
tasks of modern medicinal chemistry. In general, the solution to this problem comes down to …
tasks of modern medicinal chemistry. In general, the solution to this problem comes down to …
Quinoline‐1, 3‐Oxazole hybrids: syntheses, anticancer activity and molecular docking studies
In continuation of the synthesis of potent quinoline based anticancer agents, a series of
novel quinoline‐1, 3‐oxazole hybrids 15 a‐l were synthesized by the condensation reaction …
novel quinoline‐1, 3‐oxazole hybrids 15 a‐l were synthesized by the condensation reaction …
Analysis of plant-derived phytochemicals as anti-cancer agents targeting cyclin dependent kinase-2, human topoisomerase IIa and vascular endothelial growth factor …
Cancer is caused by a variety of pathways, involving numerous types of enzymes. Among
them three enzymes ie Cyclin-dependent kinase-2 (CDK-2), Human topoisomerase IIα, and …
them three enzymes ie Cyclin-dependent kinase-2 (CDK-2), Human topoisomerase IIα, and …