The expression of the human Ki‐67 protein is strictly associated with cell proliferation.
During interphase, the antigen can be exclusively detected within the nucleus, whereas in …

The Rb protein is a tumor suppressor, which plays a pivotal role in the negative control of the
cell cycle and in tumor progression. It has been shown that Rb protein (pRb) is responsible …

The tumor suppressor gene p53 plays a major role in regulation of the mammalian cellular
stress response, in part through the transcriptional activation of genes involved in cell cycle …

The general mechanisms that control the cell cycle in mammalian cells have been studied in
depth and several proteins that are involved in the tight regulation of cell cycle progression …

Inactivation of p53-dependent apoptosis promotes oncogenic transformation, tumor
development, and resistance to many cytotoxic anticancer agents. p53 can transcriptionally …

Epidemiological, in vitro cell culture, and in vivo animal studies have shown that green tea or
its constituent polyphenols, particularly its major polyphenol epigallocatechin-3-gallate …

p130 is a tumor suppressor of the pocket protein family whose expression is
posttranscriptionally regulated and largely G0 restricted. The mechanism of down-regulation …

The transcription factor E2F plays a major role in cell cycle control in mammalian cells. E2F
binding sites, which are present in the promoters of a variety of genes required for S phase …

The multistep nature of cancer development provides a rationale for cancer prevention.
Activation of oncogenes, inactivation of tumor suppressor genes and modulation of …

Ten structurally related 2′-oxygenated chalcone derivatives, bearing either hydroxy and/or
methoxy substituents on the A and B rings, were synthesized through Claisen–Schmidt …