Oxidatively induced DNA damage and its repair in cancer
M Dizdaroglu - Mutation Research/Reviews in Mutation Research, 2015 - Elsevier
Oxidatively induced DNA damage is caused in living organisms by endogenous and
exogenous reactive species. DNA lesions resulting from this type of damage are mutagenic …
exogenous reactive species. DNA lesions resulting from this type of damage are mutagenic …
DNA glycosylases in the base excision repair of DNA
HE Krokan, R Standal, G Slupphaug - Biochemical Journal, 1997 - portlandpress.com
A wide range of cytotoxic and mutagenic DNA bases are removed by different DNA
glycosylases, which initiate the base excision repair pathway. DNA glycosylases cleave the …
glycosylases, which initiate the base excision repair pathway. DNA glycosylases cleave the …
Mutagenicity, toxicity and repair of DNA base damage induced by oxidation
S Bjelland, E Seeberg - Mutation Research/Fundamental and Molecular …, 2003 - Elsevier
Oxidative DNA damage is a major cause of cell death and mutagenesis in all aerobic
organisms, and several new oxidative base lesions have been identified in recent years …
organisms, and several new oxidative base lesions have been identified in recent years …
Biological consequences of free radical-damaged DNA bases
SS Wallace - Free Radical Biology and Medicine, 2002 - Elsevier
The principal oxidized cytosine bases, uracil glycol, 5-hydroxycytosine, and 5-hydroxyuracil,
are readily bypassed, miscode, and are thus important premutagenic lesions. Similarly the …
are readily bypassed, miscode, and are thus important premutagenic lesions. Similarly the …
Mutagenicity and repair of oxidative DNA damage: insights from studies using defined lesions
D Wang, DA Kreutzer, JM Essigmann - Mutation Research/Fundamental …, 1998 - Elsevier
Oxidative DNA damage has been implicated in mutagenesis, carcinogenesis and aging.
Endogenous cellular processes such as aerobic metabolism generate reactive oxygen …
Endogenous cellular processes such as aerobic metabolism generate reactive oxygen …
Enzymatic processing of radiation-induced free radical damage in DNA
SS Wallace - Radiation research, 1998 - meridian.allenpress.com
A significant fraction of DNA damage produced by ionizing radiation comes from free
radicals generated during the radiolysis of water, that is, by indirect effects. The hydroxyl …
radicals generated during the radiolysis of water, that is, by indirect effects. The hydroxyl …
Base excision repair in yeast and mammals
A Memisoglu, L Samson - Mutation Research/Fundamental and Molecular …, 2000 - Elsevier
Base excision repair (BER), as initiated by at least seven different DNA glycosylases or by
enzymes that cleave DNA at abasic sites, executes the repair of a wide variety of DNA …
enzymes that cleave DNA at abasic sites, executes the repair of a wide variety of DNA …
Oxidative DNA damage repair in mammalian cells: a new perspective
Oxidatively induced DNA lesions have been implicated in the etiology of many diseases
(including cancer) and in aging. Repair of oxidatively damaged bases in all organisms …
(including cancer) and in aging. Repair of oxidatively damaged bases in all organisms …
Molecular cloning and functional expression of a human cDNA encoding the antimutator enzyme 8-hydroxyguanine-DNA glycosylase
T Roldán-Arjona, YF Wei, KC Carter… - Proceedings of the …, 1997 - National Acad Sciences
The major mutagenic base lesion in DNA caused by exposure to reactive oxygen species is
8-hydroxyguanine (8-oxo-7, 8-dihydroguanine). In bacteria and Saccharomyces cerevisiae …
8-hydroxyguanine (8-oxo-7, 8-dihydroguanine). In bacteria and Saccharomyces cerevisiae …
Toward a Detailed Understanding of Base Excision Repair Enzymes: Transition State and Mechanistic Analyses of N-Glycoside Hydrolysis and N-Glycoside …
PJ Berti, JAB McCann - Chemical reviews, 2006 - ACS Publications
This review focuses on the chemistry performed by base excision repair (BER) enzymes,
enzymes that remove nucleobases from DNA in the first step of the repair of many types of …
enzymes that remove nucleobases from DNA in the first step of the repair of many types of …