The BAP1 gene has emerged as a major tumor suppressor mutated with various
frequencies in numerous human malignancies, including uveal melanoma, malignant …

BAP1 is a ubiquitin C-terminal hydrolase domain-containing deubiquitinase with a wide
array of biological activities. Studies in which advanced sequencing technologies were used …

The deubiquitinating enzyme BAP1 is a tumor suppressor, among others involved in
cholangiocarcinoma. BAP1 has many proposed molecular targets, while its Drosophila …

Biallelic inactivation of the tumour suppressor gene Von Hippel–Lindau (VHL) occurs in the
vast majority of clear cell renal cell carcinoma (ccRCC) instances, disrupting cellular oxygen …

Thymic carcinoma is rare and has a poorer prognosis than thymomas. The treatment options
are limited after failure of platinum-based chemotherapy. We previously performed a single …

Abstract BRCA1-Associated Protein 1 (BAP1) is a ubiquitin carboxy-terminal hydrolase that
has been established as a tumor suppressor, utilizing its deubiquitinating activity to regulate …

Deubiquitinating enzymes (DUBs) are a large group of proteases that reverse ubiquitination
process and maintain protein homeostasis. The DUBs have been classified into seven …

Malignant mesothelioma (MMe) is a cancer with poor prognosis and resistance to standard
treatments. Recent reports have highlighted the role of the BRCA1 associated protein 1 …

Purpose: The clinical standard treatment for patients with malignant pleural mesothelioma
(MPM) includes a cisplatin-based chemotherapy, leading to reduction of tumor size in only a …

The transcription factor MYCN is frequently amplified and overexpressed in a variety of
cancers including high-risk neuroblastoma (NB) and promotes tumor cell proliferation …