The Runx family of transcription factors (Runx1, Runx2, and Runx3) are highly conserved
and encode proteins involved in a variety of cell lineages, including blood and blood-related …

Embryonic definitive hematopoiesis generates hematopoietic stem and progenitor cells
(HSPCs) essential for establishment and maintenance of the adult blood system. This …

The Echinodermata are an ancient phylum of benthic marine invertebrates with a dispersal-
stage planktonic larva. These animals have innate immune systems characterized initially by …

Genome-wide combinatorial binding patterns for key transcription factors (TFs) have not
been reported for primary human hematopoietic stem and progenitor cells (HSPCs), and …

During embryonic development, adult haematopoietic stem cells (HSCs) emerge
preferentially in the ventral domain of the aorta in the aorta–gonad–mesonephros (AGM) …

The formation of spatiotemporal patterns of gene expression is frequently guided by
gradients of diffusible signaling molecules. The toggle switch subnetwork, composed of two …

Transcription factor (TF) networks determine cell-type identity by establishing and
maintaining lineage-specific expression profiles, yet reconstruction of mammalian regulatory …

In this paper, the stability and bifurcations of a new discrete chaotic map based on gene
regulatory network are studied. Firstly, the existence and stability conditions of the fixed …

Acute myeloid leukemia (AML) is a complex disease characterized by a diverse range of
recurrent molecular aberrations that occur in many different combinations. Components of …

Highlights•Compartment-specific activation of σ F and σ E requires a threshold Spo0A
activity.•Inhibition of KinA by Spo0F results in a delayed negative feedback in the …