Synthetic biology is the discipline of engineering application-driven biological functionalities
that were not evolved by nature. Early breakthroughs of cell engineering, which were based …

Microneedle (MN) technologies have gained interest for biomedical applications, ranging
from drug delivery to sensing and tissue sampling in skin and internal organs. The …

Engineered genetic circuits for mammalian cells often require extensive fine-tuning to
perform as intended. We present a robust, general, scalable system, called'Boolean logic …

A fundamental challenge in synthetic biology is to create molecular circuits that can program
complex cellular functions. Because proteins can bind, cleave, and chemically modify one …

Synthetic biology concerns the engineering of man‐made living biomachines from
standardized components that can perform predefined functions in a (self‐) controlled …

In living organisms, naturally evolved sensors that constantly monitor and process
environmental cues trigger corrective actions that enable the organisms to cope with …

Optogenetic tools can provide fine spatial and temporal control over many biological
processes. Yet the development of new light-switchable protein variants remains …

Engineering synthetic gene regulatory circuits proceeds through iterative cycles of design,
building, and testing. Initial circuit designs must rely on often-incomplete models of …

Synthetic RNA-based genetic devices dynamically control a wide range of gene-regulatory
processes across diverse cell types. However, the limited throughput of quantitative assays …

Advances in synthetic biology have enabled the engineering of cells with genetic circuits in
order to program cells with new biological behavior, dynamic gene expression, and logic …