Medicinal attributes of 1, 2, 3-triazoles: Current developments

D Dheer, V Singh, R Shankar - Bioorganic Chemistry, 2017 - Elsevier
Triazoles are important five-membered heterocyclic scaffold due to their extensive biological
activities. This framework can be readily obtained in good to excellent yields on the …

Click chemistry: 1, 2, 3‐triazoles as pharmacophores

SG Agalave, SR Maujan… - Chemistry–An Asian …, 2011 - Wiley Online Library
Abstract The copper (I)‐catalyzed 1, 2, 3‐triazole‐forming reaction between azides and
terminal alkynes has become the gold standard of 'click chemistry'due to its reliability …

Design and synthesis of novel 1, 2, 3-triazole-dithiocarbamate hybrids as potential anticancer agents

YC Duan, YC Ma, E Zhang, XJ Shi, MM Wang… - European journal of …, 2013 - Elsevier
A series of novel 1, 2, 3-triazole-dithiocarbamate hybrids were designed, synthesized and
evaluated for anticancer activity against four selected human tumor cell lines (MGC-803 …

Recent advancements in 1, 4-disubstituted 1H-1, 2, 3-triazoles as potential anticancer agents

K Lal, P Yadav - Anti-Cancer Agents in Medicinal Chemistry …, 2018 - ingentaconnect.com
Cancer is a class of formidable disease with high degree of mortality. Despite much
progress in chemotherapy, the problem of drug resistance has led to the search for newer …

Method for assigning structure of 1, 2, 3-triazoles

X Creary, A Anderson, C Brophy… - The Journal of organic …, 2012 - ACS Publications
1, 4-Disubstituted-1 H-1, 2, 3-triazoles 1 can easily be distinguished from the isomeric 1, 5-
disubstituted-1 H-1, 2, 3-triazoles 2 by simple one-dimensional 13C NMR spectroscopy …

Application of triazoles as bioisosteres and linkers in the development of microtubule targeting agents

MS Malik, SA Ahmed, II Althagafi, MA Ansari… - RSC Medicinal …, 2020 - pubs.rsc.org
The triazole ring system has emerged as an exciting prospect in the optimization studies of
promising lead molecules in the quest for new drugs for clinical usage. Several marketed …

Benzothiazole-[1, 2, 3] triazolo [5, 1-a] isoindoles: Synthesis, anticancer activity, bioavailability and in silico studies against Gama-Tubulin protein

M Kumar, SK Nukala, M Ravinder, TM Krishna… - Journal of Molecular …, 2022 - Elsevier
We, herein, reported the CuI catalyzed synthesis of some novel fused benzothiazole-1, 2, 3-
triazole hybrids (5a-5o) in one-pot. The in vitro anticancer activity of these compounds …

New structural scaffolds for centrally acting oxime reactivators of phosphylated cholinesterases

RK Sit, Z Radić, V Gerardi, L Zhang, E Garcia… - Journal of Biological …, 2011 - ASBMB
We describe here the synthesis and activity of a new series of oxime reactivators of
cholinesterases (ChEs) that contain tertiary amine or imidazole protonatable functional …

Design and synthesis of novel 1, 2, 3-triazole–pyrimidine–urea hybrids as potential anticancer agents

LY Ma, B Wang, LP Pang, M Zhang, SQ Wang… - Bioorganic & Medicinal …, 2015 - Elsevier
Abstract A series of novel 1, 2, 3-triazole–pyrimidine–urea hybrids were designed,
synthesized and evaluated for anticancer activity against four selected cancer cell lines …

Design, synthesis and antiproliferative activity studies of novel 1, 2, 3-triazole–dithiocarbamate–urea hybrids

YC Duan, YC Zheng, XC Li, MM Wang, XW Ye… - European journal of …, 2013 - Elsevier
A series of novel 1, 2, 3-triazole–dithiocarbamate–urea hybrids were designed, synthesized
and their antiproliferative activities against four selected human cancer cell lines were …