Nearly 350 IgG-based therapeutics are approved for clinical use or are under development
for many diseases lacking adequate treatment options. These include molecularly …

Because the bovine mammary gland is constantly challenged by a variety of contagious and
environmental pathogens, maintenance of mammary health may be best thought of in terms …

This report of the American Dairy Science Association Committee on the Nomenclature,
Classification, and Methodology of Milk Proteins reviews changes in the nomenclature of …

We describe here the functional implications of an increase in IgG binding to the neonatal Fc
receptor. We have defined in a systematic fashion the relationship between enhanced FcRn …

Preclinical tests of therapeutic antibodies are frequently carried out in mice to evaluate
pharmacokinetics and efficacy. However, the observation that mouse IgG are cleared rapidly …

Abstract The neonatal Fc receptor (FcRn) transports immunoglobulin G (IgG) across
epithelia, binding IgG in acidic vesicles (pH≤ 6.5) and releasing IgG in the blood at pH 7.4 …

Abstract The neonatal Fc receptor (FcRn) for IgG, an MHC class I-related molecule, functions
to transport IgG across polarized epithelial cells and protect IgG from degradation. However …

The neonatal Fc receptor (FcRn) performs two distinct but related functions: transport of
maternal immunoglobulin G (IgG) to pre-or neonatal mammals, thus providing passive …

Careful regulation of the body's immunoglobulin G (IgG) and albumin concentrations is
necessitated by the importance of their respective functions. As such, the neonatal Fc …

The prepartum transfer of immunoglobulins from maternal circulation into mammary
secretions, ie, colostrogenesis, is a distinct stage of mammary gland development …