The glutathione peroxidase family: Discoveries and mechanism
The discoveries leading to our present understanding of the glutathione peroxidases (GPxs)
are recalled. The cytosolic GPx, now GPx1, was first described by Mills in 1957 and claimed …
are recalled. The cytosolic GPx, now GPx1, was first described by Mills in 1957 and claimed …
Glutathione-related enzymes and proteins: a review
The tripeptide glutathione is found in all eukaryotic cells, and due to the
compartmentalization of biochemical processes, its synthesis takes place exclusively in the …
compartmentalization of biochemical processes, its synthesis takes place exclusively in the …
Regulatory phenomena in the glutathione peroxidase superfamily
R Brigelius-Flohé, L Flohé - Antioxidants & redox signaling, 2020 - liebertpub.com
Significance: The selenium-containing Glutathione peroxidases (GPxs) 1–4 protect against
oxidative challenge, inhibit inflammation and oxidant-induced regulated cell death. Recent …
oxidative challenge, inhibit inflammation and oxidant-induced regulated cell death. Recent …
The thioredoxin antioxidant system
J Lu, A Holmgren - Free radical biology and medicine, 2014 - Elsevier
The thioredoxin (Trx) system, which is composed of NADPH, thioredoxin reductase (TrxR),
and thioredoxin, is a key antioxidant system in defense against oxidative stress through its …
and thioredoxin, is a key antioxidant system in defense against oxidative stress through its …
Glutathione peroxidases
R Brigelius-Flohé, M Maiorino - … et Biophysica Acta (BBA)-General Subjects, 2013 - Elsevier
BACKGROUND: With increasing evidence that hydroperoxides are not only toxic but rather
exert essential physiological functions, also hydroperoxide removing enzymes have to be re …
exert essential physiological functions, also hydroperoxide removing enzymes have to be re …
[HTML][HTML] Glutathione catalysis and the reaction mechanisms of glutathione-dependent enzymes
M Deponte - Biochimica et Biophysica Acta (BBA)-General Subjects, 2013 - Elsevier
BACKGROUND: Glutathione-dependent catalysis is a metabolic adaptation to chemical
challenges encountered by all life forms. In the course of evolution, nature optimized …
challenges encountered by all life forms. In the course of evolution, nature optimized …
Signaling functions of reactive oxygen species
We review signaling by reactive oxygen species, which is emerging as a major physiological
process. However, among the reactive oxygen species, H2O2 best fulfills the requirements …
process. However, among the reactive oxygen species, H2O2 best fulfills the requirements …
Glutathione peroxidase family–an evolutionary overview
Glutathione peroxidases (EC 1.11. 1.9 and EC 1.11. 1.12) catalyze the reduction of H2O2 or
organic hydroperoxides to water or corresponding alcohols using reduced glutathione …
organic hydroperoxides to water or corresponding alcohols using reduced glutathione …
Proximity-based protein thiol oxidation by H2O2-scavenging peroxidases*♦
M Gutscher, MC Sobotta, GH Wabnitz… - Journal of Biological …, 2009 - ASBMB
H 2 O 2 acts as a signaling molecule by oxidizing critical thiol groups on redox-regulated
target proteins. To explain the efficiency and selectivity of H 2 O 2-based signaling, it has …
target proteins. To explain the efficiency and selectivity of H 2 O 2-based signaling, it has …
Multiple functions of peroxiredoxins: peroxidases, sensors and regulators of the intracellular messenger H2O2, and protein chaperones
SG Rhee, HA Woo - 2011 - liebertpub.com
Peroxiredoxins (Prxs) are a family of peroxidases that reduce peroxides, with a conserved
cysteine residue (the peroxidatic Cys) serving as the site of oxidation by peroxides …
cysteine residue (the peroxidatic Cys) serving as the site of oxidation by peroxides …