IL-2 was first identified as a growth factor capable of driving the expansion of activated
human T cell populations. In the more than 40 years since its discovery, a tremendous …

▪ Abstract Cytokines and interferons are molecules that play central roles in the regulation of
a wide array of cellular functions in the lympho-hematopoietic system. These factors …

The existence of interleukin (IL)-2 has been recognized for over 25 years, and it remains one
of the most extensively studied cytokines. Here we present a broad overview of IL-2 history …

The activation of Stat5 proteins (Stat5a and Stat5b) is one of the earliest signaling events
mediated by IL-2 family cytokines, allowing the rapid delivery of signals from the membrane …

In this review, we discuss the role of cytokines and their signaling pathways in
immunodeficiency. We focus primarily on severe combined immunodeficiency (SCID) …

Publisher Summary This chapter provides an overview of receptor activation from
biochemical and cellular studies regarding immune system development and function when …

Abstract Interleukin-21 (IL-21) is a type I cytokine that modulates functions of T, B, natural
killer (NK), and myeloid cells. The IL-21 receptor (IL-21R) is closely related to the IL-2 …

Since the discovery of their physiological roles in cytokine signalling, the Janus kinases
(JAKs) and the signal transducers and activators of transcription (STATs) have attracted …

Studies assessing the role of Stat5 in the IL-2 proliferative signal have produced
contradictory, and thus inconclusive, results. One factor confounding many of these studies …

Interleukin (IL-) 2 and its receptor (IL-2R) constitute one of the most extensively studied
cytokine receptor systems. IL-2 is produced primarily by activated T cells and is involved in …