Mechanisms of receptor tyrosine kinase activation in cancer
Receptor tyrosine kinases (RTKs) play an important role in a variety of cellular processes
including growth, motility, differentiation, and metabolism. As such, dysregulation of RTK …
including growth, motility, differentiation, and metabolism. As such, dysregulation of RTK …
Therapeutic advances of targeting receptor tyrosine kinases in cancer
Receptor tyrosine kinases (RTKs), a category of transmembrane receptors, have gained
significant clinical attention in oncology due to their central role in cancer pathogenesis …
significant clinical attention in oncology due to their central role in cancer pathogenesis …
Targeting cancer with kinase inhibitors
S Gross, R Rahal, N Stransky… - The Journal of …, 2015 - Am Soc Clin Investig
Kinase inhibitors have played an increasingly prominent role in the treatment of cancer and
other diseases. Currently, more than 25 oncology drugs that target kinases have been …
other diseases. Currently, more than 25 oncology drugs that target kinases have been …
[HTML][HTML] Allostery in disease and in drug discovery
R Nussinov, CJ Tsai - Cell, 2013 - cell.com
Allostery is largely associated with conformational and functional transitions in individual
proteins. This concept can be extended to consider the impact of conformational …
proteins. This concept can be extended to consider the impact of conformational …
Massive parallel sequencing uncovers actionable FGFR2–PPHLN1 fusion and ARAF mutations in intrahepatic cholangiocarcinoma
Intrahepatic cholangiocarcinoma (iCCA) is a fatal bile duct cancer with dismal prognosis and
limited therapeutic options. By performing RNA-and exome-sequencing analyses, we report …
limited therapeutic options. By performing RNA-and exome-sequencing analyses, we report …
PDGF receptor mutations in human diseases
E Guérit, F Arts, G Dachy, B Boulouadnine… - Cellular and Molecular …, 2021 - Springer
PDGFRA and PDGFRB are classical proto-oncogenes that encode receptor tyrosine kinases
responding to platelet-derived growth factor (PDGF). PDGFRA mutations are found in …
responding to platelet-derived growth factor (PDGF). PDGFRA mutations are found in …
Detection, characterization, and inhibition of FGFR–TACC fusions in IDH wild-type glioma
AL Di Stefano, A Fucci, V Frattini, M Labussiere… - Clinical cancer …, 2015 - AACR
Purpose: Oncogenic fusions consisting of fibroblast growth factor receptor (FGFR) and
TACC are present in a subgroup of glioblastoma (GBM) and other human cancers and have …
TACC are present in a subgroup of glioblastoma (GBM) and other human cancers and have …
Kinase regulation by liquid–liquid phase separation
TP López-Palacios, JL Andersen - Trends in Cell Biology, 2023 - cell.com
Liquid–liquid phase separation (LLPS) is emerging as a mechanism of spatiotemporal
regulation that could answer long-standing questions about how order is achieved in …
regulation that could answer long-standing questions about how order is achieved in …
PDGF receptor signaling networks in normal and cancer cells
JB Demoulin, A Essaghir - Cytokine & growth factor reviews, 2014 - Elsevier
For about four decades, platelet-derived growth factors (PDGF) and their receptors have
been the subject of intense research, revealing their roles in embryo development and …
been the subject of intense research, revealing their roles in embryo development and …
Kinase-mediated RAS signaling via membraneless cytoplasmic protein granules
Receptor tyrosine kinase (RTK)-mediated activation of downstream effector pathways such
as the RAS GTPase/MAP kinase (MAPK) signaling cascade is thought to occur exclusively …
as the RAS GTPase/MAP kinase (MAPK) signaling cascade is thought to occur exclusively …