[HTML][HTML] Learnings from 30 years of reported efficacy and safety of vagus nerve stimulation (VNS) for epilepsy treatment: a critical review

DH Toffa, L Touma, T El Meskine, A Bouthillier… - Seizure, 2020 - Elsevier
Three decades after its introduction as an adjuvant therapeutic option in the management of
selective drug-resistant epilepsy cases (DRE), vagus nerve stimulation (VNS) retains …

Vagus nerve stimulation (VNS) therapy update

JW Wheless, AJ Gienapp, P Ryvlin - Epilepsy & behavior, 2018 - Elsevier
Epilepsy affects millions of people worldwide. Approximately one-third have
pharmacoresistant epilepsy, and of these, the majority are not candidates for epilepsy …

Vagal nerve stimulation: a review of its applications and potential mechanisms that mediate its clinical effects

DA Groves, VJ Brown - Neuroscience & Biobehavioral Reviews, 2005 - Elsevier
Vagal nerve stimulation (VNS) is an approved treatment for epilepsy and is currently under
investigation as a therapy for other disorders, including depression, anxiety and Alzheimer's …

Noninvasive techniques for probing neurocircuitry and treating illness: vagus nerve stimulation (VNS), transcranial magnetic stimulation (TMS) and transcranial direct …

MS George, G Aston-Jones - Neuropsychopharmacology, 2010 - nature.com
Although the preceding chapters discuss much of the new knowledge of neurocircuitry of
neuropsychiatric diseases, and an invasive approach to treatment, this chapter describes …

Neurostimulation of the cholinergic anti-inflammatory pathway ameliorates disease in rat collagen-induced arthritis

YA Levine, FA Koopman, M Faltys, A Caravaca… - PloS one, 2014 - journals.plos.org
Introduction The inflammatory reflex is a physiological mechanism through which the
nervous system maintains immunologic homeostasis by modulating innate and adaptive …

[HTML][HTML] Latest views on the mechanisms of action of surgically implanted cervical vagal nerve stimulation in epilepsy

R Carron, P Roncon, S Lagarde, M Dibué… - … : Technology at the …, 2023 - Elsevier
Background Vagus nerve stimulation (VNS) is approved as an adjunctive treatment for drug-
resistant epilepsy. Although there is a substantial amount of literature aiming at unraveling …

Vagus nerve stimulation therapy, epilepsy, and device parameters: scientific basis and recommendations for use

C Heck, SL Helmers, CM DeGiorgio - Neurology, 2002 - AAN Enterprises
Our understanding of a precise dose-response relationship for vagus nerve stimulation
(VNS) therapy in the treatment of seizures is still evolving. Because several parameters are …

Recordings from the rat locus coeruleus during acute vagal nerve stimulation in the anaesthetised rat

DA Groves, EM Bowman, VJ Brown - Neuroscience letters, 2005 - Elsevier
Vagal nerve stimulation (VNS) is used as a treatment for Epilepsy and is currently under
investigation as a treatment for depression (see [MS George, Z. Nahas, X. Li, FA Kozel, B …

Vagus nerve stimulation in children with intractable epilepsy: a randomized controlled trial

S Klinkenberg, MW Aalbers, JSH Vles… - … Medicine & Child …, 2012 - Wiley Online Library
Aim The aim of this study was to evaluate the effects of vagus nerve stimulation (VNS) in
children with intractable epilepsy on seizure frequency and severity and in terms of …

Spatially selective stimulation of the pig vagus nerve to modulate target effect versus side effect

SL Blanz, ED Musselman, ML Settell… - Journal of neural …, 2023 - iopscience.iop.org
Electrical stimulation of the cervical vagus nerve using implanted electrodes (VNS) is FDA-
approved for the treatment of drug-resistant epilepsy, treatment-resistant depression, and …