Neuroblastoma derived from primitive cells of the sympathetic nervous system typically
develops in the adrenal medulla or paraspinal ganglia. Neuroblastoma usually occurs …

Sonic hedgehog (Shh) plays important roles in developmental of vertebrate animal central
nervous system (CNS), and Gli is its downstream signal molecule. Shh signalling is …

Activating mutations in the gene encoding β-catenin have been identified in the paediatric
form of human craniopharyngioma (adamantinomatous craniopharyngioma, ACP), a …

Emerging laboratory and clinical investigations demonstrate that Hedgehog signaling (Hh)
represents a novel therapeutic target in various human cancers. This conserved signaling …

Craniopharyngiomas are benign but locally invasive tumours of the sellar region that occur
as two subtypes. The adamantinomatous type (aCP) occurs mainly during childhood while …

Abstract The Hedgehog (Hh) signaling pathway is critical for embryonic development. In
adult tissues, Hh signaling is relatively quiescent with the exception of roles in tissue …

Hedgehog (HH) signaling is an important regulator of embryogenesis that has been
associated with the development of several types of cancer. HH signaling is characterized …

Aberrant activation of hedgehog (Hh) signaling has been observed in a wide variety of
tumors and accounts for more than 25% of human cancer deaths. Inhibitors targeting the Hh …

Oxidative stress is one of the most important pathological mechanisms in neurodegenerative
diseases and ischemia. Recent studies have indicated that the sonic hedgehog (SHH) …

Abstract Background The Hedgehog signaling pathway functions as an organizer in
embryonic development. Recent studies have demonstrated constitutive activation of …