Highly dynamic mitotic spindle microtubules are superb therapeutic targets for a group of
chemically diverse and clinically successful anticancer drugs. Microtubule-targeted drugs …

Cancer is one of the greatest challenges of the modern medicine. Although much effort has
been made in the development of novel cancer therapeutics, it still remains one of the most …

Chemotherapeutics are sometimes administered with drugs, like antiangiogenic
compounds, to increase their effectiveness. Melatonin exerts antitumoral actions through …

Extensive research over the last decade has resulted in a number of highly potent tubulin
polymerization inhibitors acting either as microtubule stabilizing agents (MSAs) or …

Microtubules are pivotal in diverse cellular functions encompassing cell signaling,
morphology, intracellular trafficking, and cell mitosis/division. They are validated targets for …

Covering: 2000 up to 2016 Peloruside A, a macrocyclic secondary metabolite from a New
Zealand marine sponge, Mycale hentscheli, has shown potent antiproliferative activity in …

Zampanolide, first discovered in a sponge extract in 1996 and later identified as a
microtubule-stabilizing agent in 2009, is a covalent binding secondary metabolite with …

Microtubules (MTs) play an essential role in mitosis; hence they are identified as potential
targets to design novel anti-mitotic agents. MT's are composed of α/β-tubulin isotypes that …

Cysteine-rich secretory proteins (CRISPs), characterized by 16 conserved cysteines, are
distributed in a wide range of organisms, such as secernenteas, amphibians, reptiles and …

Anticancer drugs based on the microtubules target are potent mitotic spindle poison agents,
which interact directly with the microtubules, and were classified as microtubule-stabilizing …