Despite the widespread use of antineoplastic platinum drugs, a number of accompanying
disadvantages exist. In connection with attempts to circumvent these problems new platinum …

Platinum compounds induce their cytotoxic effect by binding to a DNA molecule in the form
of a platinum-DNA-adduct. Many previous studies have shown that the level of platinum …

After the second edition introduced first density functional theory aspects, this third edition
expands on this topic and offers unique practice in molecular mechanics calculations and …

Bases in the opposite strands of DNA cross-linked by clinically ineffective trans-
diamminedichloroplatinum (II)(trans-[Pt (NH3) 2Cl2]) have been identified by means of three …

Telomerase, a ribonucleoprotein, elongates and/or maintains telomeres by adding TTAGGG
tandem repeat sequences using the RNA component of the enzyme as a template. Enzyme …

Department of Chemistry, Massachusetts Institute of Technology, Cambridge,
Massachusetts 02139 Received July 18, 1991; Revised Manuscript Received November 27 …

Publisher Summary This chapter presents a discussion on the interactions of platinum
amine biomolecules and DNA fragments compounds with sulfur-containing biomolecules …

Cisplatin is a simple inorganic compound which has proved to be a very effective anticancer
drug, especially against testicular tumors. The compound has therapeutic limitations based …

Molecular Modulation of Surfactant Aggregation in Water: Effect of the Incorporation of
Multiple Headgroups on Micellar Properties This work was supported by a grant from the …

The reaction between trans-dlammlnedichloroplatinum (ll) and single-stranded
oligonucleotides containing the sequence d (GXG)(X being an adenlne, cytosine or thymlne …