Cellular mechanotransduction, a critical regulator of numerous biological processes, is the
conversion from mechanical signals to biochemical signals regarding cell activities and …

In chronic infection, inflammation and cancer, the tissue microenvironment controls how
local immune cells behave, with tissue-resident fibroblasts emerging as a key cell type in …

Physical stimuli are essential for the function of eukaryotic cells, and changes in physical
signals are important elements in normal tissue development as well as in disease initiation …

Here, using single-cell RNA sequencing, we examine the stromal compartment in murine
melanoma and draining lymph nodes (LNs) at points across tumor development, providing …

BACKGROUND Keloid and hypertrophic scars represent an aberrant response to the wound
healing process. These scars are characterized by dysregulated growth with excessive …

Pathological fibrosis is driven by a feedback loop in which the fibrotic extracellular matrix is
both a cause and consequence of fibroblast activation. However, the molecular mechanisms …

Solid tumors are characterized by an abnormal stroma that contributes to the development of
biomechanical abnormalities in the tumor microenvironment. In particular, these …

Tissue injury disrupts the mechanical homeostasis that underlies normal tissue architecture
and function. The failure to resolve injury and restore homeostasis gives rise to progressive …

Cellular crosstalk is a process through which a message is transmitted within an individual
cell (intracellular crosstalk) or between different cells (intercellular crosstalk). Intercellular …

Background/Aims We studied the role of lysyl oxidase-like 2 (LOXL2) in collagen
crosslinking and hepatic progenitor cell (HPC) differentiation, and the therapeutic efficacy of …