This review examines the association of a subset of endothelial nitric oxide synthase gene
(NOS3) polymorphisms (Glu298Asp, intron 4, and-786T> C) with cardiovascular disease …

Background: Endothelial dysfunction is thought to play an important role in the pathogenesis
and progression of cerebral small-vessel disease in lacunar stroke patients. Methods: We …

Background and Purpose—Genetic influences are important in multifactorial cerebral small-
vessel disease (SVD) and may act via endothelial dysfunction. Nitric oxide (NO) synthesized …

The present observations examined the hypothesis that the iNOS expression in the ischemic
penumbra after a transient focal ischemic insult is involved in the recruitment of penumbra …

Single‐gene disorders explain only a minority of stroke cases. Stroke represents a complex
trait, which is usually assumed to be polygenic. On this topic, the role of a wide number of …

Stroke is a heterogeneous multifactorial disease and is thought to have a polygenic basis.
Case–control studies on gene sequence variations have identified a number of potential …

OBJECTIVE: To analyze potential associations of Glu-Asp298 polymorphism in exon 7 and
4 a/b polymorphism in intron 4 of the endothelial nitric oxide synthase (eNOS) gene with …

The recent completion of the Human Genome Project has provided an unprecedented
opportunity for researchers to identify high-risk patients and improve human health through …

Background and Purpose—Endothelial nitric oxide exerts a variety of protective effects on
endothelial cells and blood vessels, and therefore the nitric oxide synthase 3 gene (NOS3) …

Cerebral small vessel disease results from ischaemia in the perforating arteries supplying
the white matter and deep grey matter nuclei. It results in both focal lacunar infarction and …