The number of cancer cases caused by being obese is estimated to be 20% with the
increased risk of malignancies being influenced by diet, weight change, and body fat …

The mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK)
pathway is frequently mutated in human cancer. This pathway consists of a small GTP …

Body mass index, as an approximation of body adiposity, is associated with increased risk of
several common and less common malignancies in a sex-and site-specific manner. These …

Patients with poorly differentiated thyroid cancers (PDTC), anaplastic thyroid cancers (ATC),
and radioactive iodine-refractory (RAIR) differentiated thyroid cancers have a high mortality …

The Mitogen Activated Protein Kinase (MAPK) pathway plays a key role in melanoma
development making it an important therapeutic target. In normal cells, the tightly regulated …

The mitogen-activated protein kinase (MAPK) cascade is an intracellular signaling pathway
involved in the regulation of cellular proliferation and the survival of tumor cells. Several …

BRAF is a member of the RAF kinase family, which acts in the ERK/MAP kinase pathway, a
signalling cascade that regulates cellular proliferation, differentiation and survival. Single …

Melanoma is the deadliest form of skin cancer. While associated survival prognosis is good
when diagnosed early, it dramatically drops when melanoma progresses into its metastatic …

In recent years, melanoma has become a poster-child for the development of oncogene-
directed targeted therapies. This approach, which has been exemplified by the development …

The prognosis of patients with metastatic melanoma is poor and not influenced by systemic
therapy with cytotoxic drugs. New targeted agents directed against the RAS-RAF-MEK-ERK …