[HTML][HTML] Biomarkers of aging for the identification and evaluation of longevity interventions
With the rapid expansion of aging biology research, the identification and evaluation of
longevity interventions in humans have become key goals of this field. Biomarkers of aging …
longevity interventions in humans have become key goals of this field. Biomarkers of aging …
Single-cell analyses of aging, inflammation and senescence
Single-cell gene expression (transcriptomics) data are becoming robust and abundant, and
are increasingly used to track organisms along their life-course. This allows investigation …
are increasingly used to track organisms along their life-course. This allows investigation …
Aging is associated with a systemic length-associated transcriptome imbalance
Aging is among the most important risk factors for morbidity and mortality. To contribute
toward a molecular understanding of aging, we analyzed age-resolved transcriptomic data …
toward a molecular understanding of aging, we analyzed age-resolved transcriptomic data …
[HTML][HTML] Individual cell types in C. elegans age differently and activate distinct cell-protective responses
Aging is characterized by a global decline in physiological function. However, by
constructing a complete single-cell gene expression atlas, we find that Caenorhabditis …
constructing a complete single-cell gene expression atlas, we find that Caenorhabditis …
Multi‐omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming
D Chondronasiou, D Gill, L Mosteiro, RG Urdinguio… - Aging …, 2022 - Wiley Online Library
The expression of the pluripotency factors OCT4, SOX2, KLF4, and MYC (OSKM) can
convert somatic differentiated cells into pluripotent stem cells in a process known as …
convert somatic differentiated cells into pluripotent stem cells in a process known as …
The activity of early-life gene regulatory elements is hijacked in aging through pervasive AP-1-linked chromatin opening
A mechanistic connection between aging and development is largely unexplored. Through
profiling age-related chromatin and transcriptional changes across 22 murine cell types …
profiling age-related chromatin and transcriptional changes across 22 murine cell types …
[HTML][HTML] Molecular and cytological profiling of biological aging of mouse cochlear inner and outer hair cells
Age-related hearing loss (ARHL) negatively impacts quality of life in the elderly population.
The prevalent cause of ARHL is loss of mechanosensitive cochlear hair cells (HCs). The …
The prevalent cause of ARHL is loss of mechanosensitive cochlear hair cells (HCs). The …
Spatial and single-cell profiling of the metabolome, transcriptome and epigenome of the aging mouse liver
C Nikopoulou, N Kleinenkuhnen, S Parekh, T Sandoval… - Nature aging, 2023 - nature.com
Tissues within an organism and even cell types within a tissue can age with different
velocities. However, it is unclear whether cells of one type experience different aging …
velocities. However, it is unclear whether cells of one type experience different aging …
Delineating mouse β-cell identity during lifetime and in diabetes with a single cell atlas
Although multiple pancreatic islet single-cell RNA-sequencing (scRNA-seq) datasets have
been generated, a consensus on pancreatic cell states in development, homeostasis and …
been generated, a consensus on pancreatic cell states in development, homeostasis and …
Molecular hallmarks of heterochronic parabiosis at single-cell resolution
The ability to slow or reverse biological ageing would have major implications for mitigating
disease risk and maintaining vitality. Although an increasing number of interventions show …
disease risk and maintaining vitality. Although an increasing number of interventions show …