Sepsis is a common complication of combat injuries and trauma, and is defined as a life-
threatening organ dysfunction caused by a dysregulated host response to infection. It is also …

Triggering receptors expressed on myeloid cells (TREMs) encompass a family of cell-
surface receptors chiefly expressed by granulocytes, monocytes and tissue macrophages …

Sepsis is a life-threatening medical condition that occurs when the host has an uncontrolled
or abnormal immune response to overwhelming infection. It is now widely accepted that …

Extracellular vesicles (EVs) have been identified as novel mediators of intercellular
communication. They work via delivering the sequestered cargo to cells in the close vicinity …

Neutrophil migration into the site of infection is necessary for antibacterial innate defense,
whereas impaired neutrophil migration may result in excessive inflammation and even …

The mechanisms linking systemic infection to hyperinflammation and immune dysfunction in
sepsis are poorly understood. Extracellular histones promote sepsis pathology, but their …

Impairment of innate immune cell function and metabolism underlies immunosuppression in
sepsis; however, a promising therapy to orchestrate this impairment is currently lacking. In …

Aims Cytokine storm is closely related to the initiation and progression of sepsis, and the
level of IL-6 is positively correlated with mortality and organ dysfunction. Sepsis-induced …

Background Septic shock occurs when sepsis is related to severe hypotension and leads to
a remarkable high number of deaths. The early diagnosis of septic shock is essential to …

Intensive care unit (ICU)-acquired infection is a common cause of poor prognosis of sepsis
in the ICU. However, sepsis-associated ICU-acquired infections have not been fully …