Analysis of the equilibrium distribution of ligands in heterogeneous media–Approaches and pitfalls
The equilibrium distribution of small molecules (ligands) between binding agents in
heterogeneous media is an important property that determines their activity. Heterogeneous …
heterogeneous media is an important property that determines their activity. Heterogeneous …
Development of adapalene loaded liposome based gel for acne
Retinoids are considered the mainstay treatment for moderate to severe acne. Adapalene, a
third-generation retinoid, has physiochemical properties which hinder the effective delivery …
third-generation retinoid, has physiochemical properties which hinder the effective delivery …
[HTML][HTML] Research Progress of Phospholipid Vesicles in Biological Field
N Zhang, J Song, Y Han - Biomolecules, 2024 - mdpi.com
Due to their high biocompatibility, biodegradability, and facile surface functionalization,
phospholipid vesicles as carriers have garnered significant attention in the realm of disease …
phospholipid vesicles as carriers have garnered significant attention in the realm of disease …
How to tackle the issues in free energy simulations of long amphiphiles interacting with lipid membranes: convergence and local membrane deformations
One of the great challenges in membrane biophysics is to find a means to foster the
transport of drugs across complex membrane structures. In this spirit, we elucidate …
transport of drugs across complex membrane structures. In this spirit, we elucidate …
1,4-β-d-Glucomannan from Dendrobium officinale Activates NF-кB via TLR4 to Regulate the Immune Response
YP Huang, TB He, XD Cuan, XJ Wang, JM Hu, J Sheng - Molecules, 2018 - mdpi.com
2, 3-O-acetylated-1, 4-β-d-glucomannan (DOP-1-1) is a polysaccharide isolated from the
stem of Dendrobium officinale. DOP-1-1 has been demonstrated to have remarkable …
stem of Dendrobium officinale. DOP-1-1 has been demonstrated to have remarkable …
Unravelling a mechanism of action for a cecropin A-melittin hybrid antimicrobial peptide: the induced formation of multilamellar lipid stacks
An understanding of the mechanism of action of antimicrobial peptides is fundamental to the
development of new and more active antibiotics. In the present work, we use a wide range of …
development of new and more active antibiotics. In the present work, we use a wide range of …
[HTML][HTML] Evaluation of the passive permeability of antidepressants through pore-suspended lipid bilayer
Hypothesis The antidepressant drug imipramine, and its metabolite desipramine show
different extents of interaction with, and passive permeation through, cellular membrane …
different extents of interaction with, and passive permeation through, cellular membrane …
In-vitro binding analysis of bovine serum albumin with sulindac/chlorpromazine: Spectroscopic, calorimetric and computational approaches
S Khatun, FA Qais - Journal of Molecular Liquids, 2020 - Elsevier
The current study was undertaken to explore the bindingof sulindac (SDC), and
chlorpromazine (CPZ) with the bovine serum albumin (BSA) by fluorescence, isothermal …
chlorpromazine (CPZ) with the bovine serum albumin (BSA) by fluorescence, isothermal …
Interaction of Hoechst 33342 with POPC Membranes at Different pH Values
Hoechst 33342 (H33342) is a fluorescent probe that is commonly used to stain the DNA of
living cells. To do so, it needs to interact with and permeate through cell membranes, despite …
living cells. To do so, it needs to interact with and permeate through cell membranes, despite …
Permeation of a homologous series of nbd-labeled fatty amines through lipid bilayers: A molecular dynamics study
Permeation through biomembranes is ubiquitous for drugs to reach their active sites.
Asymmetry of the cell plasma membrane (PM) has been described as having an important …
Asymmetry of the cell plasma membrane (PM) has been described as having an important …