Vaccines and therapeutics for immunocompromised patients with COVID-19

S Shoham, C Batista, YB Amor, O Ergonul… - …, 2023 - thelancet.com
The COVID-19 pandemic has disproportionately impacted immunocompromised patients.
This diverse group is at increased risk for impaired vaccine responses, progression to …

Systematic review and meta‐analysis of the clinical effectiveness of tixagevimab/cilgavimab for prophylaxis of COVID‐19 in immunocompromised patients

R Suribhatla, T Starkey, MC Ionescu… - British Journal of …, 2023 - Wiley Online Library
Immunocompromised patients, such as those with a haematological malignancy, are at
higher risk of SARS‐CoV‐2 infection, severe outcomes and mortality. Tixagevimab …

Tixagevimab/cilgavimab in SARS-CoV-2 prophylaxis and therapy: A comprehensive review of clinical experience

K Akinosoglou, EA Rigopoulos, G Kaiafa, S Daios… - Viruses, 2022 - mdpi.com
Effective treatments and vaccines against COVID-19 used in clinical practice have made a
positive impact on controlling the spread of the pandemic, where they are available …

Efficacy and safety of tixagevimab/cilgavimab to prevent COVID-19 (pre-exposure prophylaxis): a systematic review and meta-analysis

S Alhumaid, A Al Mutair, J Alali, N Al Dossary… - Diseases, 2022 - mdpi.com
Background: Tixagevimab/cilgavimab (TGM/CGM) are neutralizing monoclonal antibodies
(mAbs) directed against different epitopes of the receptor-binding domain of the SARS-CoV …

[HTML][HTML] Real-world effectiveness of tixagevimab and cilgavimab (Evusheld) in patients with hematological malignancies

AJ Ocon, KE Ocon, J Battaglia, SK Low… - Journal of …, 2022 - ncbi.nlm.nih.gov
Background Immunocompromised individuals with hematological malignancy have
increased risk for poor outcomes and death from severe acute respiratory syndrome …

An overview of the development of pharmacotherapeutics targeting SARS-CoV-2

T Lucaj, I Hay, A Samarbakhsh, M Bedi, AK Iyer… - Drug Discovery …, 2024 - Elsevier
Abstract Coronavirus disease 2019 (COVID-19) was declared a global pandemic in March
2020, which precipitated urgent public health responses. The causative agent, SARS-CoV …

Neutralizing activity against Omicron BA. 5 after tixagevimab/cilgavimab administration comparable to those after Omicron BA. 1/BA. 2 breakthrough infections

J Yang, G Won, JY Baek, YH Lee, H Kim… - Frontiers in …, 2023 - frontiersin.org
Introduction The effect of tixagevimab/cilgavimab (Evusheld™; AstraZeneca, UK) should be
evaluated in the context of concurrent outbreak situations. Methods For serologic …

Health outcomes and cost-effectiveness of monoclonal SARS-CoV-2 antibodies as pre-exposure prophylaxis

S Popping, BE Nichols, B Appelman… - JAMA Network …, 2023 - jamanetwork.com
Importance Pre-exposure prophylaxis with neutralizing SARS-CoV-2 monoclonal antibodies
(mAbs PrEP) prevents infection and reduces hospitalizations and the duration thereof for …

Ruxolitinib treatment in myelofibrosis and polycythemia vera causes suboptimal humoral immune response following standard and booster vaccination with …

GA Palumbo, D Cambria, E La Spina… - Frontiers in …, 2023 - frontiersin.org
Patients affected by myelofibrosis (MF) or polycythemia vera (PV) and treated with ruxolitinib
are at high risk for severe coronavirus disease 2019. Now a vaccine against the virus SARS …

[HTML][HTML] Predictors of SARS-CoV-2 Omicron breakthrough infection after receipt of AZD7442 (tixagevimab-cilgavimab) for pre-exposure prophylaxis among …

JC Laracy, J Yan, SN Steiger, CA Tan, N Cohen… - …, 2023 - ncbi.nlm.nih.gov
Abstract AZD7442 (tixagevimab-cilgavimab) is a combination of two human monoclonal
antibodies for pre-exposure prophylaxis of severe acute respiratory syndrome coronavirus 2 …