The brain is a singular organ of unique biological complexity that serves as the command
center for cognitive and motor function. As such, this specialized system also possesses a …

Copper is too redox active to exist in an unbound form in the cell without causing oxidative
damage: an upper limit of 10-18 M for the free concentration of Cu (II) in unstressed cells has …

A pathological hallmark of Alzheimer's disease is an accumulation of insoluble plaque
containing the amyloid-β peptide of 40–42 amino acid residues. Prefibrillar, soluble …

Alzheimer's disease is the leading cause of dementia in the elderly and is defined by two
pathological hallmarks; the accumulation of aggregated amyloid beta and excessively …

There are a group of diseases associated with protein misfolding and accumulation into
amyloid fibers. Many of these diseases have a major impact on human health, in particular …

Prion diseases are transmissible spongiform encephalopathies (TSEs), attributed to
conformational conversion of the cellular prion protein (PrPC) into an abnormal conformer …

Prion diseases are caused by conversion of a normal cell-surface glycoprotein (PrPC) into a
conformationally altered isoform (PrPSc) that is infectious in the absence of nucleic acid …

The aggregation of α-synuclein (AS) is characteristic of Parkinson's disease and other
neurodegenerative synucleinopathies. Interactions with metal ions affect dramatically the …

A role for PrP in the toxic effect of oligomeric forms of Aβ, implicated in Alzheimer's disease
(AD), has been suggested but remains controversial. Here we show that PrP is required for …

The existence and functioning of intrinsically disordered proteins (IDPs) challenge the
classical structure-function paradigm that equates function with a well-defined 3D structure …