B cell receptor (BCR) signalling is crucial for normal B cell development and adaptive
immunity. BCR signalling also supports the survival and growth of malignant B cells in …

Tumor-associated macrophages (TAMs) play a central role in tumor progression, metastasis,
and recurrence after treatment. Macrophage plasticity and diversity allow their classification …

Hematological malignancies (HM) are a collection of malignant transformations originating
from cells in the primary or secondary lymphoid organs. Leukemia, lymphoma, and multiple …

To identify new therapeutic targets in acute myeloid leukemia (AML), we performed small-
molecule and small-interfering RNA (siRNA) screens of primary AML patient samples. In …

Despite progress in exploiting therapeutically the genetic vulnerabilities of leukemia and
lymphoma, the outcome is often extended progression-free survival but not tumor …

A large amount of circumstantial evidence has accumulated suggesting that Toll-like
receptor (TLR) signals are involved in driving chronic lymphocytic leukemia (CLL) cell …

Simple Summary Tumor-associated macrophages (TAM) represent a leading component of
the tumor microenvironment in hematologic malignancies. TAM could display antitumor …

Self-renewal and multidirectional differentiation of hematopoietic stem cells (HSCs) are
strictly regulated by numerous cellular components and cytokines in the bone marrow (BM) …

Microenvironment contributes to follicular lymphoma (FL) pathogenesis and impacts survival
with macrophages playing a controversial role. In the present study, using FL primary …

Translating the genetic and epigenetic heterogeneity underlying human cancers into
therapeutic strategies is an ongoing challenge. Large-scale sequencing efforts have …