S100A8 and S100A9 (also known as MRP8 and MRP14, respectively) are Ca2+ binding
proteins belonging to the S100 family. They often exist in the form of heterodimer, while …

Alzheimer's disease (AD) is a debilitating neurological disorder, and currently, there is no
cure for it. Several pathologic alterations have been described in the brain of AD patients …

Alzheimer's disease (AD) is the most common form of dementia and it is characterized by the
deposition of amyloid-β (Aβ) plaques and neurofibrillary tangles in the brain. However, the …

The intestinal microbiome releases a plethora of small molecules. Here, we show that the
Ruminococcaceae metabolite isoamylamine (IAA) is enriched in aged mice and elderly …

S100 proteins are calcium-binding proteins that regulate several processes associated with
Alzheimer's disease (AD) but whose contribution and direct involvement in disease …

Alzheimer's disease (AD) is the most common form of dementia worldwide. Accumulating
evidence indicates that non-coding RNAs are strongly implicated in AD-associated …

The S100 family proteins possess a variety of intracellular and extracellular functions. They
interact with multiple receptors and signal transducers to regulate pathways that govern …

Rationale: Sepsis causes brain dysfunction and neuroinflammation. It is unknown whether
neuroinflammation in sepsis is initiated by dissemination of bacteria to the brain and …

S100 proteins are small proteins that are only expressed in vertebrates. They are widely
expressed in many different cell types and are involved in the regulation of calcium …

Alterations in cholesterol metabolism in the brain have a major role in the physiology of
Alzheimer's disease (AD). Oxysterols are cholesterol metabolites with multiple implications …