Highlights•There is a strong association between C. albicans morphology and virulence.•C.
albicans morphology control mechanisms may serve as important antifungal …

The yeast-to-hyphal transition (dimorphism) of the most common human pathogenic yeast
Candida albicans remains in the focus of molecular and medical mycology [1-4]. Since our …

Candida albicans surface-attached biofilms such as those formed on intravenous catheters
with direct access to the bloodstream often serve as a nidus for continuous release of cells …

In vivo transcriptional analyses of microbial pathogens are often hampered by low
proportions of pathogen biomass in host organs, hindering the coverage of full pathogen …

The human fungal pathogen Candida albicans develops drug resistance after long-term
exposure to azole drugs in the treatment of chronic candidiasis. Gain-of-function (GOF) …

Transcriptionally silent heterochromatin is associated with repetitive DNA. It is poorly
understood whether and how heterochromatin differs between different organisms and …

Mediator is a complex of polypeptides that plays a central role in the recruitment of RNA
polymerase II to promoters and subsequent transcriptional activation in eukaryotic …

DNA repeats, found at the ribosomal DNA locus, telomeres and subtelomeric regions, are
unstable sites of eukaryotic genomes. A fine balance between genetic variability and …

Whether to commit limited cellular resources toward growth and proliferation, or toward
survival and stress responses, is an essential determination made by Target of Rapamycin …

The Candida albicans genome contains between ten and fifteen distinct TLO genes that all
encode a Med2 subunit of Mediator. In order to investigate the biological role of Med2/Tlo in …