A Review of ex vivo Elemental Mapping Methods to Directly Image Changes in the Homeostasis of Diffusible Ions (Na+, K+, Mg2 +, Ca2 +, Cl) Within Brain …

D Hartnell, W Andrews, N Smith, H Jiang… - Frontiers in …, 2020 - frontiersin.org
Diffusible ions (Na+, K+, Mg2+, Ca2+, Cl–) are vital for healthy function of all cells, especially
brain cells. Unfortunately, the diffusible nature of these ions renders them difficult to study …

[HTML][HTML] A review of the “metallome” within neurons and glia, as revealed by elemental mapping of brain tissue

G Ellison, AL Hollings, MJ Hackett - BBA advances, 2022 - Elsevier
It is now well established that transition metals, such as Iron (Fe), Copper (Cu), and Zinc (Zn)
are necessary for healthy brain function. Although Fe, Cu, and Zn are essential to the brain …

In situ biospectroscopic investigation of rapid ischemic and postmortem induced biochemical alterations in the rat brain

MJ Hackett, CJ Britz, PG Paterson… - ACS chemical …, 2015 - ACS Publications
Rapid advances in imaging technologies have pushed novel spectroscopic modalities such
as Fourier transform infrared spectroscopy (FTIR) and X-ray absorption spectroscopy (XAS) …

Infrared spectroscopic characterization of monocytic microvesicles (microparticles) released upon lipopolysaccharide stimulation

J Lee, B Wen, EA Carter, V Combes… - The FASEB …, 2017 - Wiley Online Library
Microvesicles (MVs) are involved in cell‐cell interactions, including disease pathogenesis.
Nondestructive Fourier‐transform infrared (FTIR) spectra from MVs were assessed as a …

Direct in vivo imaging of essential bioinorganics in Caenorhabditis elegans

SA James, MD de Jonge, DL Howard, AI Bush… - Metallomics, 2013 - academic.oup.com
Metals are essential in biochemistry, with highly regulated localisation and concentration. To
continue elucidating the impact of inorganic physiology on cellular process in health and …

Mechanisms of murine cerebral malaria: Multimodal imaging of altered cerebral metabolism and protein oxidation at hemorrhage sites

MJ Hackett, JB Aitken, F El-Assaad, JA McQuillan… - Science …, 2015 - science.org
Using a multimodal biospectroscopic approach, we settle several long-standing
controversies over the molecular mechanisms that lead to brain damage in cerebral malaria …

FTIR imaging of brain tissue reveals crystalline creatine deposits are an ex vivo marker of localized ischemia during murine cerebral malaria: general implications for …

MJ Hackett, J Lee, F El-Assaad… - ACS chemical …, 2012 - ACS Publications
Phosphocreatine is a major cellular source of high energy phosphates, which is crucial to
maintain cell viability under conditions of impaired metabolic states, such as decreased …

Light and heavy ion beam analysis of thin biological sections

J Lee, R Siegele, Z Pastuovic, MJ Hackett… - Nuclear Instruments and …, 2013 - Elsevier
The application of ion beam analysis (IBA) techniques to thin biological sections (ThBS)
presents unique challenges in sample preparation, data acquisition and analysis. These …

Investigation of elemental changes in brain tissues following excitotoxic injury

R Siegele, NR Howell, PD Callaghan… - Nuclear Instruments and …, 2013 - Elsevier
Recently the ANSTO heavy ion microprobe has been used for elemental mapping of thin
brain tissue sections. The fact that a very small portion of the proton energy is used for X-ray …

Application of infrared spectroscopy in the study of neurological diseases

S Turker - Biomedical Spectroscopy and Imaging, 2012 - content.iospress.com
Infrared (IR) spectroscopy, as one the most common spectroscopic techniques, has been
developed in terms of both instrumentation and analysis methods. This allows the wide …