Acute symptomatic seizures secondary to autoimmune encephalitis and autoimmune‐associated epilepsy: conceptual definitions

C Steriade, J Britton, RC Dale, A Gadoth, SR Irani… - …, 2020 - Wiley Online Library
Seizures are a well‐recognized and often prominent manifestation of autoimmune
encephalitic syndromes. Progress in detection of pathogenic neural autoantibodies has led …

The role of inflammation in epilepsy

A Vezzani, J French, T Bartfai, TZ Baram - Nature reviews neurology, 2011 - nature.com
Epilepsy is the third most common chronic brain disorder, and is characterized by an
enduring predisposition to generate seizures. Despite progress in pharmacological and …

The compartmentalized inflammatory response in the multiple sclerosis brain is composed of tissue-resident CD8+ T lymphocytes and B cells

J Machado-Santos, E Saji, AR Tröscher, M Paunovic… - Brain, 2018 - academic.oup.com
Multiple sclerosis is an inflammatory demyelinating disease in which active demyelination
and neurodegeneration are associated with lymphocyte infiltrates in the brain. However, so …

Rasmussen's encephalitis: clinical features, pathobiology, and treatment advances

S Varadkar, CG Bien, CA Kruse, FE Jensen… - The Lancet …, 2014 - thelancet.com
Rasmussen's encephalitis is a rare chronic neurological disorder, characterised by
unilateral inflammation of the cerebral cortex, drug-resistant epilepsy, and progressive …

Immunopathology of autoantibody-associated encephalitides: clues for pathogenesis

CG Bien, A Vincent, MH Barnett, AJ Becker, I Blümcke… - Brain, 2012 - academic.oup.com
Classical paraneoplastic encephalitis syndromes with 'onconeural'antibodies directed to
intracellular antigens, and the recently described paraneoplastic or non-paraneoplastic …

Neuroinflammation: an integrating overview of reactive‐Neuroimmune cell interactions in health and disease

R Kölliker-Frers, L Udovin… - Mediators of …, 2021 - Wiley Online Library
The concept of central nervous system (CNS) inflammation has evolved over the last
decades. Neuroinflammation is the response of reactive CNS components to altered …

Epilepsy and brain inflammation

A Vezzani, E Aronica, A Mazarati, QJ Pittman - Experimental neurology, 2013 - Elsevier
During the last decade, experimental research has demonstrated a prominent role of glial
cells, activated in brain by various injuries, in the mechanisms of seizure precipitation and …

Cortical demyelination and diffuse white matter injury in multiple sclerosis

A Kutzelnigg, CF Lucchinetti, C Stadelmann, W Brück… - Brain, 2005 - academic.oup.com
Focal demyelinated plaques in white matter, which are the hallmark of multiple sclerosis
pathology, only partially explain the patient's clinical deficits. We thus analysed global brain …

The immunopathology of multiple sclerosis: an overview

H Lassmann, W Brück, CF Lucchinetti - Brain pathology, 2007 - Wiley Online Library
Multiple sclerosis (MS) is traditionally seen as an inflammatory demyelinating disease,
characterized by the formation of focal demyelinated plaques in the white matter of the …

Inflammation in neurodegenerative disease—a double-edged sword

T Wyss-Coray, L Mucke - Neuron, 2002 - cell.com
Inflammation is a defense reaction against diverse insults, designed to remove noxious
agents and to inhibit their detrimental effects. It consists of a dazzling array of molecular and …