Metastasis is the most complex and deadly event. Tumor-stromal interface is a place where
invasion of tumor cells in the form of single-cell or collective migration occurs, with the latter …

TMPRSS2 is a type II transmembrane protease with broad expression in epithelial cells of
the respiratory and gastrointestinal tract, the prostate, and other organs. Although the …

Abstract Transmembrane protease, serine 2 (TMPRSS2) has been identified as key host cell
factor for viral entry and pathogenesis of SARS-CoV-2. Specifically, TMPRSS2 …

The ongoing COVID-19 pandemic has already caused over a million deaths worldwide, and
this death toll will be much higher before effective treatments and vaccines are available …

Abstract Particulate matter 2.5 (PM2. 5) is a risk factor for lung cancer. In this study, we
investigated the molecular mechanisms of PM2. 5 exposure on lung cancer progression. We …

Transmembrane protease serine 2 (TMPRSS2) is a membrane-bound protease expressed
in many human epithelial tissues, including the airway and lung. TMPRSS2-mediated …

Serine proteases are members of a large family of hydrolytic enzymes in which a particular
serine residue in the active site performs an essential role as a nucleophile, which is …

A vast ensemble of extracellular proteins influences the development and progression of
cancer, shaped and reshaped by a complex network of extracellular proteases. These …

Despite the development of vaccines against the severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) virus, there is an urgent need for efficient drugs to treat infected …

Prostate cancer is one of the most common malignant diseases in men, and it contributes
significantly to the increased mortality rate in men worldwide. This study aimed to review the …