The generation of the components that make up the embryonic body axis, such as the spinal
cord and vertebral column, takes place in an anterior-to-posterior (head-to-tail) direction …

Spinal cord injury (SCI) can lead to severe motor, sensory and social impairments having a
huge impact on patients' lives. The complex and time-dependent SCI pathophysiology has …

The mammalian brain develops through a complex interplay of spatial cues generated by
diffusible morphogens, cell–cell interactions and intrinsic genetic programs that result in …

Mammalian embryogenesis is characterized by rapid cellular proliferation and
diversification. Within a few weeks, a single-cell zygote gives rise to millions of cells …

WNT signalling has multiple roles. It maintains pluripotency of embryonic stem cells, assigns
posterior identity in the epiblast and induces mesodermal tissue. Here we provide evidence …

During the trunk-to-tail transition, axial progenitors relocate from the epiblast to the tail bud.
Here, we show that this process entails a major regulatory switch, bringing tail bud …

The neural crest (NC) is a multipotent embryonic cell population that generates distinct cell
types in an axial position-dependent manner. The production of NC cells from human …

During early development the vertebrate embryo elongates through a combination of tissue
shape change, growth and progenitor cell expansion across multiple regions of the body …

Animal organs exhibit complex topologies involving cavities and tubular networks, which
underlie their form and function,–. However, how topology emerges during the development …

Formation of the vertebrate postcranial body axis follows two sequential but distinct phases.
The first phase generates pre-sacral structures (the so-called primary body) through the …