The recent clinical availability of the PARP inhibitor olaparib (Lynparza) opens the door for
potential therapeutic repurposing for non‐oncological indications. Considering (a) the …

Poly-adenosine diphosphate-ribose polymerase (PARP) implements posttranslational mono-
or poly-ADP-ribosylation modification of target proteins. Among the known 18 members in …

Background Abnormal activation of microglia is involved in the pathogenesis of
schizophrenia. Minocycline and antipsychotics have been reported to be effective in …

Bacillus subtilis is an intestinal probiotic for immune homeostasis and its exopolysaccharide
(EPS) is known to possess anti-inflammatory and antioxidant properties. The underlying …

Drug repositioning, or the identification of new indications for known drugs, is a useful
strategy for drug discovery. In this study, we developed novel computational methods to …

Objectives The objectives of the study were to determine if adjunctive minocycline mitigates
depressive symptom severity and improves cognitive function in individuals with bipolar I/II …

Background An important portion of asthmatics do not respond to current therapies. Thus,
the need for new therapeutic drugs is urgent. We have demonstrated a critical role for PARP …

Background Increasing evidence has shown the close link between energy metabolism and
the differentiation, function, and longevity of immune cells. Chronic inflammatory conditions …

Substantial evidence supports the critical role of NF-κB in ovarian cancer. Minocycline, a
tetracycline, has been shown to exhibit beneficial effects in this malignancy through …

Background To date, several studies have confirmed that driving forces of the inflammatory
tumour microenvironment trigger spontaneous cancer cell fusion. However, less is known …