Nanobody-based immunodiagnostics: A systematic review of nanobody integration in diagnostics and deep insight into electrochemical immunoassays

MIA Ahmad, CG Amorim, LFA Qatouseh… - Microchemical …, 2024 - Elsevier
Nanobodies (Nbs) are increasingly recognized as valuable biological molecules with
significant potential in the field of diagnostics. Their unique physiochemical characteristics …

Radiopharmaceuticals and their applications in medicine

S Zhang, X Wang, X Gao, X Chen, L Li, G Li… - … and Targeted Therapy, 2025 - nature.com
Radiopharmaceuticals involve the local delivery of radionuclides to targeted lesions for the
diagnosis and treatment of multiple diseases. Radiopharmaceutical therapy, which directly …

Synthesis, preclinical evaluation and pilot clinical translation of [68Ga]Ga-PMD22, a novel nanobody PET probe targeting CLDN18.2 of gastrointestinal cancer

R Wang, Z Bai, W Zhong, C Li, J Wang, J Xiang… - European Journal of …, 2024 - Springer
Abstract Purpose Claudin18. 2 (CLDN18. 2) is a novel target for diagnosis and therapy of
gastrointestinal cancer. This study aimed to evaluate the safety and feasibility of a novel …

Small Antibodies with Big Applications: Nanobody-Based Cancer Diagnostics and Therapeutics

Q Zhang, N Zhang, H Xiao, C Wang, L He - Cancers, 2023 - mdpi.com
Simple Summary Cancer is a leading cause of death worldwide, accounting for nearly one
in six deaths. The most common cancers are lung, breast, colon, rectum and prostate …

[HTML][HTML] Claudin18. 2-targeted cancer theranostics

D Zhang, G Huang, J Liu, W Wei - American Journal of Nuclear …, 2023 - ncbi.nlm.nih.gov
Abstract Claudin 18.2 (CLDN18. 2) is an emerging target for the treatment of CLDN18. 2-
expressing cancers such as gastric and pancreatic cancers. Cell and antibody therapies …

Recent advances in radiotracers targeting novel cancer-specific biomarkers in China: a brief overview

J Zhang, F Kang, X Wang, X Chen, X Yang… - Journal of Nuclear …, 2024 - Soc Nuclear Med
Radiopharmaceuticals play a critical role in nuclear medicine, providing novel tools for
specifically delivering radioisotopes for the diagnosis and treatment of cancers. As the …

Preparation of Radiolabeled Zolbetuximab Targeting CLDN18. 2 and Its Preliminary Evaluation for Potential Clinical Applications

Y Wang, L Ma, Z Kuang, D Li, J Yang, Y Liu… - Molecular …, 2024 - ACS Publications
Claudin18. 2 (CLDN18. 2), due to its high expression in various gastric cancer tissues, is
considered an optimal target for antitumor drug molecules. In this study, we obtained the …

Exploration of radionuclide labeling of a novel scFv-Fc fusion protein targeting CLDN18. 2 for tumor diagnosis and treatment

D Li, L Ding, Y Chen, Z Wang, Z Zeng, X Ma… - European Journal of …, 2024 - Elsevier
Abstract Purpose Claudin 18.2 (CLDN18. 2), due to its highly selective expression in tumor
cells, has made breakthrough progress in clinical research and is expected to be integrated …

Screening, construction, and preliminary evaluation of CLDN18. 2-specific peptides for noninvasive molecular imaging

Z Wang, C Zhao, J Ding, Y Chen, J Liu… - ACS Pharmacology & …, 2023 - ACS Publications
Recent global clinical trials have shown that CLDN18. 2 is an ideal target for the treatment of
gastric cancer and that patients with high CLDN18. 2 expression can benefit from targeted …

[177Lu]Lu-labeled anti-claudin-18.2 antibody demonstrated radioimmunotherapy potential in gastric cancer mouse xenograft models

Z Zeng, L Li, J Tao, J Liu, H Li, X Qian, Z Yang… - European Journal of …, 2024 - Springer
Purpose Gastric cancer (GC), one of the most prevalent and deadliest tumors worldwide, is
often diagnosed at an advanced stage with limited treatment options and poor prognosis …