Bladder cancer—the tenth most frequent cancer worldwide—has a heterogeneous natural
history and clinical behaviour. The predominant histological subtype, urothelial bladder …

Metabolic syndrome is a cluster of several metabolic abnormalities, its prevalence is
increasing worldwide. To summarize the most recent evidence regarding the relationship …

Original research: Metformin increases natural killer cell functions in head and neck squamous
cell carcinoma through CXCL1 inhibition - PMC Back to Top Skip to main content NIH NLM …

Purpose Despite a growing body of evidence indicating a potential efficacy of the anti-
diabetic metformin as anti-cancer agent, the exact mechanism underlying this efficacy has …

Background Metformin has been reported to function as the anti-tumor inhibiting the growth
of different types of cancers, including bladder cancer. But there are few reports on the roles …

The small molecules, natural antioxidant Caffeic Acid (trans-3, 4-Dihydroxycinnamic acid
CA) and anti-diabetic drug Metformin (Met), activate 5′-adenosine monophosphate …

KLF5 (Krüppel-like factor 5) plays critical roles in normal and cancer cell proliferation
through modulating cell cycle progression. In this study, we demonstrated that curcumin …

Cancer stem cells (CSCs) are a sub-population of tumor cells playing essential roles in
initiation, differentiation, recurrence, metastasis and development of drug resistance of …

Cisplatin is an extensively used chemotherapeutic drug for lung cancer, but the
development of resistance decreases its effectiveness in the treatments of non-small cell …

Results The initial search yielded 73 articles. After screening abstracts and full texts, 22
articles were included consisting of 11 animal studies and 11 clinical trials, 8 of which …