Human monocytes are divided in three major populations; classical (CD14+ CD16−), non-
classical (CD14dimCD16+), and intermediate (CD14+ CD16+). Each of these subsets is …

Current knowledge suggests that intimal smooth muscle cells (SMCs) in native
atherosclerotic plaque derive mainly from the medial arterial layer. During this process …

Vascular smooth muscle cells (VSMCs) are the major cell type in blood vessels. Unlike
many other mature cell types in the adult body, VSMC do not terminally differentiate but …

Distinct macrophage populations throughout the body display highly heterogeneous
transcriptional and epigenetic programs. Recent research has highlighted that these profiles …

Atherosclerosis is a leading cause of vascular diseases worldwide. Whereas antioxidative
therapy has been considered promising for the treatment of atherosclerosis in view of a …

Stable atherosclerotic plaques are characterized by a thick, extracellular matrix-rich fibrous
cap populated by protective ACTA2+ myofibroblast (MF)-like cells, assumed to be almost …

Atherosclerosis is a chronic inflammatory disease associated with cardiovascular
dysfunction including myocardial infarction, unstable angina, sudden cardiac death, stroke …

At least 468 individual genes have been manipulated by molecular methods to study their
effects on the initiation, promotion, and progression of atherosclerosis. Most clinicians and …

Objective—We previously showed that cholesterol loading in vitro converts mouse aortic
vascular smooth muscle cells (VSMC) from a contractile state to one resembling …

Atherosclerosis is a chronic progressive disease that involves damage to the intima,
inflammatory cell recruitment and the accumulation of lipids followed by calcification and …