Large bone defects resulting from musculoskeletal tumours, infections, or trauma are often
unable to heal spontaneously. The challenge for surgeons is to avoid amputation, and …

Osteosarcoma (OS), the most common type of primary malignant bone tumor, is defined by
the presence of malignant mesenchymal cells producing osteoid or immature bone. The …

Sequential mineralization enables the integration of minerals within the 3D structure of
hydrogels. Hydrolyzed collagen‐based hydrogels are sequentially mineralized over 10 …

Background Sterilization by gamma radiation impairs the mechanical properties of bone
allografts. Previous work related to radiation-induced embrittlement of bone tissue has been …

Background We evaluated the outcome and the survival rate of Limb salvage surgeries
(LSSs) in osteosarcoma around knee by using megaprosthesis, ECI autograft, and modified …

Background Pasteurized autograft is regarded as a biologic reconstructive option for
managing bone defects after tumor resection; however, reports on long-term outcomes from …

Aims We analyzed the long-term outcomes of patients observed over ten years after
resection en bloc and reconstruction with extracorporeal irradiated autografts Patients and …

Cortical bone allograft sterilized with a standard γ‐radiation dose of 25–35kGy has
demonstrated reduced static and cyclic fracture resistance compared with unirradiated bone …

Background The inactivation and replantation of autologous tumor bones are important
surgical methods for limb salvage in patients with malignancies. Currently, there are few …

Background In bone sarcomas, chemotherapy has improved the prognosis with advances in
diagnostic and surgical technologies, which has led to attempts to save limbs. As early …