The purinergic pathway mediates both pro-inflammatory and anti-inflammatory responses,
whereas the breakdown of adenosine triphosphate (ATP) is in a critical equilibrium. Under …

There are several hypotheses concerning the underlying pathophysiological mechanisms of
major depression, which centre largely around adaptive changes in neuronal transmission …

Major depressive disorder (MDD) is a devastating condition. Although progress has been
made in the past seven decades, patients with MDD continue to receive an inadequate …

Suicide is a major public health problem caused by a complex interaction of various factors.
Major depressive disorder (MDD) is the most prevalent psychiatric disorder associated with …

Background The prevalence of depressive disorder is increasing due to a variety of factors,
which brings a huge strain on individuals, families and society. This study aims to investigate …

Background Depression is a prevalent psychiatric disorder with high long‐term morbidities,
recurrences, and mortalities. Despite extensive research efforts spanning decades, the …

Depression is a common psychiatric disorder that brings great pain and burden to patients
and their families. However, the pathogenesis underlying the development of depression …