Forgetting as a form of adaptive engram cell plasticity
TJ Ryan, PW Frankland - Nature Reviews Neuroscience, 2022 - nature.com
One leading hypothesis suggests that memories are stored in ensembles of neurons (or
'engram cells') and that successful recall involves reactivation of these ensembles. A logical …
'engram cells') and that successful recall involves reactivation of these ensembles. A logical …
Behavioral and neurobiological mechanisms of pavlovian and instrumental extinction learning
This article reviews the behavioral neuroscience of extinction, the phenomenon in which a
behavior that has been acquired through Pavlovian or instrumental (operant) learning …
behavior that has been acquired through Pavlovian or instrumental (operant) learning …
A tissue-like neurotransmitter sensor for the brain and gut
Neurotransmitters play essential roles in regulating neural circuit dynamics both in the
central nervous system as well as at the peripheral, including the gastrointestinal tract …
central nervous system as well as at the peripheral, including the gastrointestinal tract …
Multiple routes to enhanced memory for emotionally relevant events
Events associated with aversive or rewarding outcomes are prioritized in memory. This
memory boost is commonly attributed to the elicited affective response, closely linked to …
memory boost is commonly attributed to the elicited affective response, closely linked to …
[HTML][HTML] Novel pharmacological targets in drug development for the treatment of anxiety and anxiety-related disorders
SB Sartori, N Singewald - Pharmacology & therapeutics, 2019 - Elsevier
Current medication for anxiety disorders is suboptimal in terms of efficiency and tolerability,
highlighting the need for improved drug treatments. In this review an overview of drugs …
highlighting the need for improved drug treatments. In this review an overview of drugs …
The entangled brain
L Pessoa - Journal of cognitive neuroscience, 2023 - direct.mit.edu
Abstract The Entangled Brain (Pessoa, L., 2002. MIT Press) promotes the idea that we need
to understand the brain as a complex, entangled system. Why does the complex systems …
to understand the brain as a complex, entangled system. Why does the complex systems …
A cortico-amygdala neural substrate for endocannabinoid modulation of fear extinction
Preclinical and clinical studies implicate endocannabinoids (eCBs) in fear extinction, but the
underlying neural circuit basis of these actions is unclear. Here, we employed in vivo …
underlying neural circuit basis of these actions is unclear. Here, we employed in vivo …
[HTML][HTML] Stress relief as a natural resilience mechanism against depression-like behaviors
Relief, the appetitive state after the termination of aversive stimuli, is evolutionarily
conserved. Understanding the behavioral role of this well-conserved phenomenon and its …
conserved. Understanding the behavioral role of this well-conserved phenomenon and its …
[HTML][HTML] Amygdala reward neurons form and store fear extinction memory
X Zhang, J Kim, S Tonegawa - Neuron, 2020 - cell.com
The ability to extinguish conditioned fear memory is critical for adaptive control of fear
response, and its impairment is a hallmark of emotional disorders like post-traumatic stress …
response, and its impairment is a hallmark of emotional disorders like post-traumatic stress …
Intercalated amygdala clusters orchestrate a switch in fear state
KM Hagihara, O Bukalo, M Zeller, A Aksoy-Aksel… - Nature, 2021 - nature.com
Adaptive behaviour necessitates the formation of memories for fearful events, but also that
these memories can be extinguished. Effective extinction prevents excessive and persistent …
these memories can be extinguished. Effective extinction prevents excessive and persistent …