Therapeutic potential of heterocyclic pyrimidine scaffolds

S Kumar, B Narasimhan - Chemistry Central Journal, 2018 - Springer
Heterocyclic compounds offer a high degree of structural diversity and have proven to be
broadly and economically useful as therapeutic agents. Comprehensive research on diverse …

Artificial intelligence, big data and machine learning approaches in precision medicine & drug discovery

A Nayarisseri, R Khandelwal, P Tanwar… - Current drug …, 2021 - ingentaconnect.com
Artificial Intelligence revolutionizes the drug development process that can quickly identify
potential biologically active compounds from millions of candidate within a short period. The …

Incorporating selenium into heterocycles and natural products─ from chemical properties to pharmacological activities

W Hou, H Xu - Journal of Medicinal Chemistry, 2022 - ACS Publications
Selenium (Se)-containing compounds have emerged as potential therapeutic agents for the
treatment of a range of diseases. Through tremendous effort, considerable knowledge has …

DFT, SERS-concentration and solvent dependent and docking studies of a bioactive benzenesulfonamide derivative

YS Mary, YS Mary, M Krátký, J Vinsova… - Journal of Molecular …, 2021 - Elsevier
Spectroscopic analysis, DFT studies and surface enhanced Raman scattering (SERS) of
antimicrobial bioactive 4-[(5-tert-butyl) 2-hydroxybenzylidene] amino-N-(4, 6 …

Novel fused pyridine derivatives containing pyrimidine moiety as prospective tyrosyl-tRNA synthetase inhibitors: Design, synthesis, pharmacokinetics and molecular …

IMM Othman, MAM Gad-Elkareem, M Snoussi… - Journal of Molecular …, 2020 - Elsevier
Thirteen fused pyridine derivatives have been designed, synthesized and characterized by 1
H NMR, 13 C NMR and IR spectral data and elemental analysis. Their in vitro antimicrobial …

The Synthesis, Antimicrobial Activity, and Molecular Docking of New 1, 2, 4-Triazole, 1, 2, 4-Triazepine, Quinoline, and Pyrimidine Scaffolds Condensed to Naturally …

AA Abu-Hashem, SA Al-Hussain - Pharmaceuticals, 2022 - mdpi.com
This study aims to synthesize a new series of furochromone derivatives, evaluate their
antimicrobial properties, and improve the permeability of potent compounds to inhibit …

One-pot synthesis of thiazolo [3, 2-a] pyrimidine derivatives, their cytotoxic evaluation and molecular docking studies

T Sekhar, P Thriveni, A Venkateswarlu… - … Acta Part A: Molecular …, 2020 - Elsevier
An economical, simple and efficient one-pot method has been developed for the synthesis of
thiazolo [3, 2-a] pyrimidine hydrobromide derivatives. 2, 4-diaryl-6, 7, 8, 9-tetrahydro-4 H …

[HTML][HTML] Synthesis, docking and biological evaluation of thiadiazole and oxadiazole derivatives as antimicrobial and antioxidant agents

MJN Khadri, AB Begum, MK Sunil, SA Khanum - Results in Chemistry, 2020 - Elsevier
A series of potential biological active substituted thiadiazoles 5a-j and oxadiazoles 6a-j were
obtained via a multistep synthesis sequence with a simple and convenient approach by …

Efficient synthesis and molecular docking of novel antibacterial pyrimidines and their related fused heterocyclic derivatives

SMH Sanad, AAM Ahmed… - Journal of Heterocyclic …, 2020 - Wiley Online Library
(Benzo [d][1, 3] dioxol‐5‐yl)‐1‐(thiophen‐2‐yl) prop‐2‐en‐1‐one reacted with each of
thiourea and 6‐amino‐2‐thioxo‐2, 3‐dihydropyrimidin‐4 (1H)‐one to give the …

[HTML][HTML] Design, Synthesis, Antimicrobial Activity, and Molecular Docking of Novel Thiazoles, Pyrazoles, 1, 3-Thiazepinones, and 1, 2, 4-Triazolopyrimidines Derived …

AA Abu-Hashem, SA Al-Hussain - Pharmaceuticals, 2024 - mdpi.com
Background: Recently, pyrido [2, 3-d] pyrimidine, triazolopyrimidine, thiazolopyrimidine,
quinoline, and pyrazole derivatives have gained attention due to their diverse biological …