This review covers the chemistry and biological aspects of goniothalamin-related styryl
lactones isolated from natural sources. This family of secondary metabolites has been …

Quinone methides are well-established intermediates in asymmetric synthesis. In contrast,
their extended analogues with the carbonyl and methide units distributed across two …

Abstract Cytotoxic effects of (R)-4′-methylklavuzon were investigated on hepatocellular
carcinoma cells (HuH-7 and HepG2) and HuH-7 EpCAM+/CD133+ cancer stem cells. IC 50 …

Drug discovery has a 90% rate of failure because preclinical platforms for drug testing do not
mimic the in vivo conditions. Doxorubicin (DOX) is a commonly used drug to treat breast …

Abstract Klavuzons are 6-(naphthalen-1-yl) substituted 5, 6-dihydro-2H-pyran-2-one
derivatives showing promising antiproliferative activities in variety of cancer cell lines. In this …

Abstract In this work, 2′-alkoxymethyl substituted klavuzon derivatives were prepared
starting from 2-methyl-1-naphthoic acid in eight steps. Anticancer potencies of the …

Various chemical agents are used in the treatment of Non-Small Cell Lung Cancer
(NSCLC). 2′-methylklavuzon was proposed as a potential chemotherapeutic agent in …

Breast cancer is one of the cancers with the highest incidence and mortality rates in women
in Turkey as well as in the world. Tumor micro environment comprises of cancer and normal …

One of the main objectives of studies on anticancer agents is that the agent is expected to
show a high cytotoxic activity on cancer cells and show a less cytotoxic effect on the contrary …

Hepatocellular carcinoma (HCC) is the fifth most seen cancer type and the third leading
cause of death from cancers. HCC is a fatal disease and HCC patients have a 5-year …