Synthetic lethality is a genetic interaction that results in cell death when two genetic
deficiencies co-occur but not when either deficiency occurs alone, which can be co-opted for …

Abstract Vaccinia-related kinase 1 (VRK1) is a serine/threonine kinase, for which mutations
have been reported cause to neurodegenerative diseases, including spinal muscular …

Viruses with large, double-stranded DNA genomes captured the majority of their genes from
their hosts at different stages of evolution. The origins of many virus genes are readily …

In the nucleus, the VRK1 Ser-Thr kinase is distributed in nucleoplasm and chromatin, where
it has different roles. VRK1 expression increases in response to mitogenic signals. VRK1 …

Bioluminescence assays using luciferase enzymes are widely used in research to monitor
gene expression and an array of other cell properties, and split luciferase enzymes can be …

Simple Summary Approximately half of the populations of developed countries contract
cancer, with a very high proportion of colorectal cancer among all cancer types. Food …

Histone modifications influence the recruitment of reader proteins to chromosomes to
regulate events including transcription and cell division. The idea of a histone code, where …

Epigenetic variation contributes significantly to a wide range of activities, from normal
development to human diseases through alteration of chromatin organization and gene …

Viruses with large double-stranded DNA genomes appear to have captured the majority of
their genes from the hosts at different stages of evolution. The origin of many virus genes is …

Phosphorylation of histone H3 threonine 3 (H3T3) by Haspin recruits the chromosomal
passenger complex to the inner centromere and ensures proper cell cycle progression …